DPYS

DPYS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VR2
Identifiers
Aliases	DPYS, dihydropyrimidinase, DHP, DHPase
External IDs	OMIM: 613326; MGI: 1928679; HomoloGene: 20359; GeneCards: DPYS; OMA:DPYS - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	104,467,055 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	39,720,866 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; glomerulus; ; metanephric glomerulus; ; human kidney; ; right adrenal cortex; ; left adrenal cortex; ; testicle; ; gonad; ; mucosa of paranasal sinus;
	Top expressed in
	left lobe of liver; ; primary oocyte; ; proximal tubule; ; right kidney; ; respiratory epithelium; ; olfactory epithelium; ; zygote; ; secondary oocyte; ; embryo; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	amino acid binding; zinc ion binding; metal ion binding; dihydropyrimidinase activity; phosphoprotein binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; thymine binding; uracil binding; hydrolase activity;
Cellular component	cytoplasm; cytosol; extracellular exosome;
Biological process	beta-alanine metabolic process; uracil catabolic process; pyrimidine nucleoside catabolic process; uracil metabolic process; pyrimidine nucleobase catabolic process; protein homooligomerization; protein homotetramerization; thymine catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1807
	64705
	ENSG00000147647
	ENSMUSG00000022304
	Q14117
	Q9EQF5
	NM_001385
	NM_001164466; NM_022722
	NP_001376
	NP_001157938; NP_073559
	Wikidata
View/Edit Human	View/Edit Mouse

Dihydropyrimidinase is an enzyme that in humans is encoded by the DPYS gene.⁵⁶

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.⁶

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{§ 1}

[[File:

FluoropyrimidineActivity_WP1601 — source ↗

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

Fluorouracil (5-FU) Activity edit

The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

GRCh38: Ensembl release 89: ENSG00000147647 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022304 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
"Entrez Gene: DPYS dihydropyrimidinase".

Further reading

Thomas HR, Ezzeldin HH, Guarcello V, et al. (2008). "Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism". Pharmacogenet. Genomics. 18 (1): 25–35. doi:10.1097/FPC.0b013e3282f2f134. PMID 18216719. S2CID 10940058.
Thomas HR, Ezzeldin HH, Guarcello V, et al. (2008). "Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism". Pharmacogenet. Genomics. 17 (11): 973–87. doi:10.1097/FPC.0b013e3282f01788. PMID 18075467. S2CID 23490646.
van Kuilenburg AB, Meijer J, Dobritzsch D, et al. (2007). "Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency". Mol. Genet. Metab. 91 (2): 157–64. doi:10.1016/j.ymgme.2007.02.008. PMID 17383919.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
Hamajima N, Kouwaki M, Vreken P, et al. (1998). "Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene". Am. J. Hum. Genet. 63 (3): 717–26. doi:10.1086/302022. PMC 1377410. PMID 9718352.
Naguib FN, el Kouni MH, Cha S (1985). "Enzymes of uracil catabolism in normal and neoplastic human tissues". Cancer Res. 45 (11 Pt 1): 5405–12. PMID 3931905.

[WikiPathways-7] The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147647 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022304 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8973361-5] Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.

[entrez-6] "Entrez Gene: DPYS dihydropyrimidinase".

1

2

3

4

5

6

§ 1