Article · Wikipedia archive · Last revised Jun 10, 2026

DPDPE

DPDPE is a synthetic opioid peptide and a selective agonist of the δ-opioid receptor (DOR) which is used in scientific research. It was developed in the early 1980s and was the first highly selective agonist of the DOR to be developed. It was derived from structural modification of met-enkephalin.

Last revised
Jun 10, 2026
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DPDPE
Clinical data
Other namesL-Tyrosyl-D-penicillamyl-glycyl-L-phenylalanyl-D-penicillamine (2->5)-disulfide; H-Tyr-D-Pen(1)-Gly-Phe-D-Pen(1)-OH
Identifiers
  • (4S,7S,13S)-13-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC30H39N5O7S2
Molar mass645.79 g·mol−1
3D model (JSmol)
  • CC1([C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(SS1)(C)C)C(=O)O)CC2=CC=CC=C2)NC(=O)[C@H](CC3=CC=C(C=C3)O)N)C
  • InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21-,23-,24-/m0/s1
  • Key:MCMMCRYPQBNCPH-WMIMKTLMSA-N

DPDPE ([D-Pen2,D-Pen5]enkephalin) is a synthetic opioid peptide and a selective agonist of the δ-opioid receptor (DOR) which is used in scientific research.1 It was developed in the early 1980s and was the first highly selective agonist of the DOR to be developed.1 It was derived from structural modification of met-enkephalin.2

See also

See also

References

References

  1. Tseong LF (1 September 1995). Pharmacology of Opioid Peptides. CRC Press. pp. 9–. ISBN 978-3-7186-5632-5.
  2. Kastin A, Kastin AJ (28 April 2011). Handbook of Biologically Active Peptides. Academic Press. pp. 1430–. ISBN 978-0-08-046379-7.