Article · Wikipedia archive · Last revised Jun 16, 2026

DOTMA

DOTMA, also known as 2,5-dimethoxy-3,4,6-trimethylamphetamine or as Julia, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families related to DOM. It is the 3,6-dimethyl derivative of DOM and the 6-methyl derivative of Ganesha. The drug is said to be the first and only known active phenethylamine psychedelic with a fully substituted phenyl ring. However, the cyclized FLY phenethylamines such as 2C-B-FLY also have a fully substituted phenyl ring.

Last revised
Jun 16, 2026
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DOTMA
Clinical data
Other names2,5-Dimethoxy-3,4,6-trimethylamphetamine; Julia; 3,6-Dimethyl-DOM; 6-Methyl-Ganesha
Routes of
administration		Oral1
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Pharmacokinetic data
Duration of action7–9 hours1
Identifiers
  • 1-(2,5-dimethoxy-3,4,6-trimethylphenyl)propan-2-amine
Chemical and physical data
FormulaC14H23NO2
Molar mass237.343 g·mol−1
3D model (JSmol)
  • COc1c(C)c(CC(N)C)c(c(c1C)C)OC
  • InChI=1S/C14H23NO2/c1-8(15)7-12-11(4)13(16-5)9(2)10(3)14(12)17-6/h8H,7,15H2,1-6H3
  • Key:ROGMRKPRWZWOSW-UHFFFAOYSA-N

DOTMA, also known as 2,5-dimethoxy-3,4,6-trimethylamphetamine or as Julia, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families related to DOM.1 It is the 3,6-dimethyl derivative of DOM and the 6-methyl derivative of Ganesha.1 The drug is said to be the first and only known active phenethylamine psychedelic with a fully substituted phenyl ring.1 However, the cyclized FLY phenethylamines such as 2C-B-FLY also have a fully substituted phenyl ring.1

DOTMA's dose is approximately 70 mg orally and its duration is 7 to 9 hours.1 It is less potent than DOM, which is active at doses of 3 to 10 mg, and has a shorter duration than DOM, which lasts 14 to 20 hours.1 Similarly, DOTMA is less potent and shorter-acting than Ganesha, which has a dose of 20 to 32 mg and a duration of 18 to 24 hours.1

DOTMA was described in the scientific literature by Daniel Trachsel in 2013.1 The 6-methyl-DOM analogue of DOTMA and Ganesha, Juno, is relatively unknown but may be an active psychedelic as well.1 DOTMA, or Julia, is closely related to Alexander Shulgin's "ten classic ladies".23 It is a controlled substance in Canada due to phenethylamine blanket-ban language4 but is not explicitly controlled in the United States.5

See also

See also

References

References

  1. Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. pp. 936–937. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
  2. Shulgin, Alexander; Shulgin, Ann (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628.
  3. Ger A, Ger D. "Triple Goddess of the Night". British Neuroscience Association Bulletin. 63: 28–30.
  4. "Controlled Drugs and Substances Act". Department of Justice Canada. 5 December 2025. Retrieved 20 January 2026.
  5. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
External links