DOK3

DOK3
Identifiers
Aliases	DOK3, DOKL, docking protein 3
External IDs	OMIM: 611435; MGI: 1351490; HomoloGene: 8448; GeneCards: DOK3; OMA:DOK3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,511,274 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,677,109 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; spleen; ; right lung; ; lymph node; ; bone marrow; ; upper lobe of left lung; ; trabecular bone; ; appendix;
	Top expressed in
	granulocyte; ; blood; ; spleen; ; tibiofemoral joint; ; bone marrow; ; lymph node; ; mesenteric lymph nodes; ; fetal liver hematopoietic progenitor cell; ; stroma of bone marrow; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	membrane; cytoplasm; plasma membrane; secretory granule membrane; ficolin-1-rich granule membrane;
Biological process	neutrophil degranulation; Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	79930
	27261
	ENSG00000146094
	ENSMUSG00000035711
	Q7L591
	Q9QZK7
NM_001144875; NM_001144876; NM_001308235; NM_001308236; NM_024872;
	NM_001375794; NM_001375795; NM_001375796; NM_001375797; NM_001375798; NM_001375799; NM_001384137; NM_001384138; NM_001384139
	NM_013739
NP_001138347; NP_001138348; NP_001295164; NP_001295165; NP_079148;
	NP_001362723; NP_001362724; NP_001362725; NP_001362726; NP_001362727; NP_001362728; NP_001371066; NP_001371067; NP_001371068
	NP_038767
	Wikidata
View/Edit Human	View/Edit Mouse

Docking protein 3 is a protein that in humans is encoded by the DOK3 gene.⁵⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000146094 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035711 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lemay S, Davidson D, Latour S, Veillette A (Apr 2000). "Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling". Mol Cell Biol. 20 (8): 2743–54. doi:10.1128/MCB.20.8.2743-2754.2000. PMC 85490. PMID 10733577.
Favre C, Gerard A, Clauzier E, Pontarotti P, Olive D, Nunes JA (Feb 2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900. S2CID 24417010.
"Entrez Gene: DOK3 docking protein 3".

Further reading

Cong F, Yuan B, Goff SP (2000). "Characterization of a Novel Member of the DOK Family That Binds and Modulates Abl Signaling". Mol. Cell. Biol. 19 (12): 8314–25. doi:10.1128/MCB.19.12.8314. PMC 84915. PMID 10567556.
Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J. Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Robson JD, Davidson D, Veillette A (2004). "Inhibition of the Jun N-Terminal Protein Kinase Pathway by SHIP-1, a Lipid Phosphatase That Interacts with the Adaptor Molecule Dok-3". Mol. Cell. Biol. 24 (6): 2332–43. doi:10.1128/MCB.24.6.2332-2343.2004. PMC 355862. PMID 14993273.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura SI, Natsume T, Yamanashi Y (2007). "Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases". Genes Cells. 11 (2): 143–51. doi:10.1111/j.1365-2443.2006.00926.x. PMID 16436051. S2CID 42571721.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146094 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035711 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10733577-5] Lemay S, Davidson D, Latour S, Veillette A (Apr 2000). "Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling". Mol Cell Biol. 20 (8): 2743–54. doi:10.1128/MCB.20.8.2743-2754.2000. PMC 85490. PMID 10733577.

[pmid12595900-6] Favre C, Gerard A, Clauzier E, Pontarotti P, Olive D, Nunes JA (Feb 2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900. S2CID 24417010.

[entrez-7] "Entrez Gene: DOK3 docking protein 3".

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