DNA polymerase III subunit gamma/tau

Available protein structures:
PDB	IPR012763 PF12170 (ECOD; PDBsum)
AlphaFold	IPR012763; PF12170;

DNA polymerase III tau subunit V interacting with alpha
DNA polymerase III tau subunit V interacting with alpha
Identifiers
Symbol	DNA_pol_III_sug/sutau
Pfam	PF12170
InterPro	IPR012763
PDB
Available protein structures:
PDB	IPR012763 PF12170 (ECOD; PDBsum)
AlphaFold	IPR012763; PF12170;

The τ and γ subunits are part of the DNA polymerase III holoenzyme of prokaryotes. The protein family is characterized by the well-conserved first N-terminal domain, approx. 365 amino acids. The eukaryotic equivalent to the DNA clamp loader is replication factor C, with the subunits RFC1, RFC2, RFC3, RFC4, and RFC5.

The domain is also found in plants as gene STICHEL (STI), with similarity to cyanobacterial sequences.¹ However, STI in plants is nuclear-localized and does not participate in genome duplication. It seems to instead regulate branching.²

References

Khan H, Parks N, Kozera C, Curtis BA, Parsons BJ, Bowman S, Archibald JM (August 2007). "Plastid genome sequence of the cryptophyte alga Rhodomonas salina CCMP1319: lateral transfer of putative DNA replication machinery and a test of chromist plastid phylogeny". Molecular Biology and Evolution. 24 (8): 1832–1842. doi:10.1093/molbev/msm101. PMID 17522086.
Ilgenfritz H, Bouyer D, Schnittger A, Mathur J, Kirik V, Schwab B, et al. (February 2003). "The Arabidopsis STICHEL gene is a regulator of trichome branch number and encodes a novel protein". Plant Physiology. 131 (2): 643–655. doi:10.1104/pp.014209. PMC 166840. PMID 12586888. S2CID 31931499.

This article incorporates text from the public domain Pfam and InterPro: IPR012763

[1] Khan H, Parks N, Kozera C, Curtis BA, Parsons BJ, Bowman S, Archibald JM (August 2007). "Plastid genome sequence of the cryptophyte alga Rhodomonas salina CCMP1319: lateral transfer of putative DNA replication machinery and a test of chromist plastid phylogeny". Molecular Biology and Evolution. 24 (8): 1832–1842. doi:10.1093/molbev/msm101. PMID 17522086.

[2] Ilgenfritz H, Bouyer D, Schnittger A, Mathur J, Kirik V, Schwab B, et al. (February 2003). "The Arabidopsis STICHEL gene is a regulator of trichome branch number and encodes a novel protein". Plant Physiology. 131 (2): 643–655. doi:10.1104/pp.014209. PMC 166840. PMID 12586888. S2CID 31931499.

1

2