DNAJC14

DNAJC14
Identifiers
Aliases	DNAJC14, DNAJ, DRIP78, HDJ3, LIP6, DnaJ heat shock protein family (Hsp40) member C14
External IDs	OMIM: 606092; MGI: 1921580; HomoloGene: 12553; GeneCards: DNAJC14; OMA:DNAJC14 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	55,830,824 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,655,315 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; mucosa of ileum; ; stromal cell of endometrium; ; granulocyte; ; smooth muscle tissue; ; monocyte; ; tibialis anterior muscle; ; appendix; ; rectum; ; prefrontal cortex;
	Top expressed in
	lacrimal gland; ; primary oocyte; ; secondary oocyte; ; granulocyte; ; right lung lobe; ; external carotid artery; ; internal carotid artery; ; lip; ; zygote; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor binding; dopamine receptor binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; extracellular exosome; endoplasmic reticulum;
Biological process	protein transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	85406
	74330
	ENSG00000135392
	ENSMUSG00000025354
	Q6Y2X3
	Q921R4
	NM_032364
	NM_028873; NM_001359824; NM_001359825
	NP_115740
	NP_083149; NP_001346753; NP_001346754
	Wikidata
View/Edit Human	View/Edit Mouse

DnaJ homolog subfamily C member 14 is a protein that in humans is encoded by the DNAJC14 gene.⁵⁶⁷

Interactions

DNAJC14 has been shown to interact with Dopamine receptor D1.⁵

References

GRCh38: Ensembl release 89: ENSG00000135392 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025354 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Bermak JC, Li M, Bullock C, Zhou QY (May 2001). "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein". Nat Cell Biol. 3 (5): 492–8. doi:10.1038/35074561. PMID 11331877. S2CID 40809366.
Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF (May 2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol Med. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.
"Entrez Gene: DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14".

Further reading

Bermak JC, Zhou QY (2004). "Accessory proteins in the biogenesis of G protein-coupled receptors". Mol. Interv. 1 (5): 282–7. PMID 14993367.
Leclerc PC, Auger-Messier M, Lanctot PM, et al. (2002). "A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling". Endocrinology. 143 (12): 4702–10. doi:10.1210/en.2002-220679. PMID 12446598.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chen J, Huang Y, Wu H, et al. (2003). "Molecular cloning and characterization of a novel human J-domain protein gene (HDJ3) from the fetal brain". J. Hum. Genet. 48 (5): 217–21. doi:10.1007/s10038-003-0012-8. PMID 12768437.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135392 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025354 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11331877-5] Bermak JC, Li M, Bullock C, Zhou QY (May 2001). "Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein". Nat Cell Biol. 3 (5): 492–8. doi:10.1038/35074561. PMID 11331877. S2CID 40809366.

[pmid11984006-6] Tchernev VT, Mansfield TA, Giot L, Kumar AM, Nandabalan K, Li Y, Mishra VS, Detter JC, Rothberg JM, Wallace MR, Southwick FS, Kingsmore SF (May 2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol Med. 8 (1): 56–64. doi:10.1007/bf03402003. PMC 2039936. PMID 11984006.

[entrez-7] "Entrez Gene: DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14".

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