Article · Wikipedia archive · Last revised Jun 4, 2026

Dichlorophen

Dichlorophen is an anticestodal agent, fungicide, germicide, and antimicrobial agent. It is used in combination with toluene for the removal of parasites such as ascarids, hookworms, and tapeworms from dogs and cats. In 2025, dichlorophen was reported to function as a tubulin binding mitotic inhibitor.

Last revised
Jun 4, 2026
Read time
≈ 1 min
Length
235 w
Citations
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Source
Wikipedia ↗
Dichlorophen
Ball-and-stick mode of the dichlorophen molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 4-Chloro-2-[(5-chloro-2-hydroxyphenyl)methyl]phenol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.002.335
Chemical and physical data
FormulaC13H10Cl2O2
Molar mass269.12 g·mol−1
3D model (JSmol)
Density1.5 g/cm3 g/cm3
Melting point177.5 °C (351.5 °F)
Solubility in water0.003 g/100 mL1 mg/mL (20 °C)
  • C1=CC(=C(C=C1Cl)CC2=C(C=CC(=C2)Cl)O)O
  • InChI=1S/C13H10Cl2O2/c14-10-1-3-12(16)8(6-10)5-9-7-11(15)2-4-13(9)17/h1-4,6-7,16-17H,5H2 ☒N
  • Key:MDNWOSOZYLHTCG-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Dichlorophen is an anticestodal agent, fungicide, germicide, and antimicrobial agent.2 It is used in combination with toluene for the removal of parasites such as ascarids, hookworms, and tapeworms from dogs and cats.3 In 2025, dichlorophen was reported to function as a tubulin binding mitotic inhibitor.4

Safety and regulation

The LD50 (oral, mouse) is 3300 mg/kg.5

References

References

  1. Lide DR (1998). Handbook of Chemistry and Physics (87 ed.). Boca Raton, Florida: CRC Press. pp. 8–118. ISBN 0-8493-0594-2.
  2. Milne, G.W.A. (Ed.). (2005). Gardner's commercially important chemicals: Synonyms, trade names, and properties. Hoboken, N.J.: Wiley-Interscience. Google Books
  3. "Code of Federal Regulations", Code of Federal Regulations, Title 21, Volume 6, U.S. Government Printing Office, 2005-04-01, retrieved 2009-05-01
  4. Baksheeva VE, La Rocca R, Allegro D, Derviaux C, Pasquier E, Roche P, Morelli X, Devred F, Golovin AV, Tsvetkov PO (2025). "NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5c01008.
  5. Fiege H, Voges HW, Hamamoto T, Umemura S, Iwata T, Miki H, Fujita Y, Buysch HJ, Garbe D, Paulus W (2007). "Phenol Derivatives". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a19_313. ISBN 978-3-527-30673-2.