Derna may refer to:
Places
- Derna District, a district in eastern Libya
- Derna, Libya, a port city in that district
- Apostolic Vicariate of Derna, a Catholic pre-diocesan jurisdiction with see in that city
- RAF Derna, a former Royal Air Force station located near Derna, Libya, during the Second World War
- Derna, Bihor, Romania, a commune
- Derna (river), Romania
- Derna Province, a province of Libya established in 1937 under Italian rule
People
- Derna Casetti (born 1959), Italian former female middle-distance and cross-country runner
- Derna Polazzo (1912–?), Italian sprinter and long jumper
