Article · Wikipedia archive · Last revised May 27, 2026

Deoxycytidine diphosphate

Deoxycytidine diphosphate is a nucleoside diphosphate. It is related to the common nucleic acid CTP, or cytidine triphosphate, with the -OH (hydroxyl) group on the 2' carbon on the nucleotide's pentose removed, and with one fewer phosphoryl group than CTP.

Last revised
May 27, 2026
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Source
Deoxycytidine diphosphate
Skeletal formula of deoxycytidine diphosphate as an anion (3- charge)
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Space-filling model of the deoxycytidine diphosphate molecule as an anion (3- charge)
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Names
IUPAC name
2′-Deoxycytidine 5′-(trihydrogen diphosphate)
Systematic IUPAC name
[(2R,3S,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxyoxolan-2-yl]methyl trihydrogen diphosphate
Other names
2'-Deoxycytidine diphosphate
Identifiers
3D model (JSmol)
ChemSpider
MeSH deoxycytidine+diphosphate
UNII
  • InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 ☒N
    Key: FTDHDKPUHBLBTL-SHYZEUOFSA-N ☒N
  • InChI=1/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1
    Key: FTDHDKPUHBLBTL-SHYZEUOFBT
  • O=P(O)(O)OP(=O)(O)OC[C@H]2O[C@@H](N/1C(=O)/N=C(/N)\C=C\1)C[C@@H]2O
Properties
C9H15N3O10P2
Molar mass 387.178 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Deoxycytidine diphosphate is a nucleoside diphosphate. It is related to the common nucleic acid CTP, or cytidine triphosphate, with the -OH (hydroxyl) group on the 2' carbon on the nucleotide's pentose removed (hence the deoxy- part of the name), and with one fewer phosphoryl group than CTP .

2'-Deoxycytidine diphosphate is abbreviated as dCDP.1

Synthesis of cytidine nucleotides

Deoxycytidine diphosphate is synthesized through the oxidation-reduction reaction of cytidine 5'-diphosphocholine which is catalyzed by the presence of ribonucleoside-diphosphate reductase.2 Additionally, ribonucleoside-diphosphate reductase is capable of binding and catalyzing both the formation of deoxyribonucleotides from ribonucleotide.3

See also

See also

References

References

  1. MeSH term, accessed Dec. 31, 2012
  2. Kandeel, Mahmoud; Al-Taher, Abdulla (2020-11-01). "Metabolic drug targets of the cytosine metabolism pathways in the dromedary camel (Camelus dromedarius) and blood parasite Trypanosoma evansi". Tropical Animal Health and Production. 52 (6): 3337–3358. doi:10.1007/s11250-020-02366-8. ISSN 1573-7438. PMID 32926292. S2CID 221722974.
  3. Torrents, Eduard (2014). "Ribonucleotide reductases: essential enzymes for bacterial life". Frontiers in Cellular and Infection Microbiology. 4: 52. doi:10.3389/fcimb.2014.00052. ISSN 2235-2988. PMC 4009431. PMID 24809024.
Further reading

Further reading