DCAF8

DCAF8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3I8E
Identifiers
Aliases	DCAF8, GAN2, H326, WDR42A, DDB1 and CUL4 associated factor 8
External IDs	OMIM: 615820; MGI: 91860; HomoloGene: 56725; GeneCards: DCAF8; OMA:DCAF8 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,262,549 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	172,024,572 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; gastric mucosa; ; body of pancreas; ; sural nerve; ; left lobe of thyroid gland; ; right hemisphere of cerebellum; ; right ovary; ; Achilles tendon; ; left ovary;
	Top expressed in
	neural layer of retina; ; muscle of thigh; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; zygote; ; aortic valve; ; ascending aorta; ; right kidney; ; spermatocyte; ; primary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	nucleoplasm; mitochondrion; cytosol; cytoplasm; Cul4-RING E3 ubiquitin ligase complex; nucleus;
Biological process	post-translational protein modification; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	50717
	98193
	ENSG00000132716
	ENSMUSG00000026554
	Q5TAQ8; Q5TAQ9
	Q8N7N5
	NM_015726
	NM_153555; NM_001357204
	NP_056541
	NP_705783; NP_001344133
	Wikidata
View/Edit Human	View/Edit Mouse

DDB1 and CUL4 associated factor 8 is a protein that in humans is encoded by the DCAF8 gene.⁵

Function

This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009].

References

GRCh38: Ensembl release 89: ENSG00000132716 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026554 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: DDB1 and CUL4 associated factor 8". Retrieved 2018-08-23.

Further reading

Li M, Wang L, Ren X, Zheng C (June 2011). "Host cell targets of tegument protein VP22 of herpes simplex virus 1". Arch. Virol. 156 (6): 1079–84. doi:10.1007/s00705-011-0960-9. PMID 21424732. S2CID 10554037.
Wu F, Wang S, Xing J, Li M, Zheng C (April 2012). "Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A)". FEBS Lett. 586 (8): 1079–85. doi:10.1016/j.febslet.2012.02.053. PMID 22500989.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132716 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026554 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DDB1 and CUL4 associated factor 8". Retrieved 2018-08-23.

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