Article · Wikipedia archive · Last revised Jul 3, 2026

Daf-8

The DAF-8 nematode gene encoding a R-SMAD protein of TGF-beta signaling pathway, which was originally found in model organism Caenorhabditis elegans. When the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4 on the surface of nematode cell, daf-8 will be phosphorylated and forms a heterodimer with daf-14, then enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.

Last revised
Jul 3, 2026
Read time
≈ 1 min
Length
117 w
Citations
2
Source
Wikipedia ↗
Dwarfin sma
Identifiers
OrganismCaenorhabditis elegans
Symboldaf-8
Entrez187612
RefSeq (mRNA)NM_059920.3
RefSeq (Prot)NP_492321.1
UniProtQ21733
Other data
ChromosomeI: 8.58 - 8.59 Mb
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StructuresSwiss-model
DomainsInterPro

The DAF-8 nematode gene encoding a R-SMAD protein of TGF-beta signaling pathway, which was originally found in model organism Caenorhabditis elegans.1 When the TGF-β ligand daf-7 binds to the TGF-β receptors daf-1/daf-4 on the surface of nematode cell, daf-8 will be phosphorylated and forms a heterodimer with daf-14, then enter to the nucleus to inhibit transcription regulated by daf-3/daf-5.2

References

References

  1. Park D, Estevez A, Riddle DL (February 2010). "Antagonistic Smad transcription factors control the dauer/non-dauer switch in C. elegans". Development. 137 (3): 477. doi:10.1242/dev.043752. PMC 2858912. PMID 20081192.
  2. Gumienny TL, Savage-Dunn C (July 2013). "TGF-β signaling in C. elegans". WormBook: 1–34. doi:10.1895/wormbook.1.22.2. PMC 5081272. PMID 23908056.