PARC (gene)

CUL9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JUF
Identifiers
Aliases	CUL9, H7AP1, PARC, 1810035I07Rik, Cul-9, mKIAA0708, cullin 9
External IDs	OMIM: 607489; MGI: 1925559; HomoloGene: 56696; GeneCards: CUL9; OMA:CUL9 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,224,587 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,857,314 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right frontal lobe; ; right hemisphere of cerebellum; ; anterior pituitary; ; granulocyte; ; right lobe of thyroid gland; ; skin of abdomen; ; skin of leg; ; spleen;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; muscle of thigh; ; spermatocyte; ; right kidney; ; cerebellar cortex; ; proximal tubule; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; ATP binding; ubiquitin protein ligase binding; metal ion binding; transferase activity;
Cellular component	cytoplasm; cullin-RING ubiquitin ligase complex; cytosol;
Biological process	microtubule cytoskeleton organization; ubiquitin-dependent protein catabolic process; regulation of mitotic nuclear division; protein ubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	23113
	78309
	ENSG00000112659
	ENSMUSG00000040327
	Q8IWT3
	Q80TT8
	NM_015089
	NM_001081335
	NP_055904
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cullin-9 is a protein that in humans is encoded by the CUL9 gene.⁵⁶⁷⁸

Interactions

PARC (gene) has been shown to interact with P53.⁷

References

GRCh38: Ensembl release 89: ENSG00000112659 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040327 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Skaar JR, Florens L, Tsutsumi T, Arai T, Tron A, Swanson SK, Washburn MP, DeCaprio JA (Mar 2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328.
Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (Nov 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492.
Nikolaev AY, Li M, Puskas N, Qin J, Gu W (Jan 2003). "Parc: a cytoplasmic anchor for p53". Cell. 112 (1): 29–40. doi:10.1016/S0092-8674(02)01255-2. PMID 12526791. S2CID 18403676.
"Entrez Gene: PARC p53-associated parkin-like cytoplasmic protein".

Further reading

Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Issaeva N, Bozko P, Enge M, et al. (2005). "Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors". Nat. Med. 10 (12): 1321–8. doi:10.1038/nm1146. PMID 15558054. S2CID 82043.
Ko HS, Kim SW, Sriram SR, et al. (2006). "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate". J. Biol. Chem. 281 (24): 16193–6. doi:10.1074/jbc.C600041200. PMID 16672220.
Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53". J. Biol. Chem. 282 (15): 11300–7. doi:10.1074/jbc.M611297200. PMID 17298945.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112659 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040327 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17332328-5] Skaar JR, Florens L, Tsutsumi T, Arai T, Tron A, Swanson SK, Washburn MP, DeCaprio JA (Mar 2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328.

[pmid10521492-6] Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (Nov 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492.

[pmid12526791-7] Nikolaev AY, Li M, Puskas N, Qin J, Gu W (Jan 2003). "Parc: a cytoplasmic anchor for p53". Cell. 112 (1): 29–40. doi:10.1016/S0092-8674(02)01255-2. PMID 12526791. S2CID 18403676.

[entrez-8] "Entrez Gene: PARC p53-associated parkin-like cytoplasmic protein".

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