CSF2RB

CSF2RB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C8P, 1EGJ, 1GH7, 2GYS, 4NKQ, 5DWU, 2NA9, 2NA8
Identifiers
Aliases	CSF2RB, CD131, CDw131, IL3RB, IL5RB, SMDP5, colony stimulating factor 2 receptor beta common subunit, betaGMR, colony stimulating factor 2 receptor subunit beta
External IDs	OMIM: 138981; MGI: 1339760; HomoloGene: 339; GeneCards: CSF2RB; OMA:CSF2RB - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	36,940,439 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,189,921 bp
RNA expression pattern
	Top expressed in
	blood; ; periodontal fiber; ; decidua; ; appendix; ; epithelium of nasopharynx; ; mononuclear cell; ; monocyte; ; bone marrow; ; bone marrow cell; ; testicle;
	Top expressed in
	mesenteric lymph nodes; ; granulocyte; ; stroma of bone marrow; ; subcutaneous adipose tissue; ; lactiferous gland; ; tibiofemoral joint; ; muscle of thigh; ; blood; ; spleen; ; Paneth cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	interleukin-3 receptor activity; interleukin-5 receptor activity; protein binding; cytokine receptor activity; protein tyrosine kinase activity; signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; granulocyte macrophage colony-stimulating factor receptor complex; intracellular anatomical structure;
Biological process	respiratory gaseous exchange by respiratory system; MAPK cascade; signal transduction; response to lipopolysaccharide; peptidyl-tyrosine phosphorylation; interleukin-5-mediated signaling pathway; cellular response to interleukin-3; interleukin-3-mediated signaling pathway; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1439
	12984
	ENSG00000100368
	ENSMUSG00000071714
	P32927
	P26954
	NM_000395
	NM_001287389; NM_007781
	NP_000386
	NP_001274318; NP_031807
	Wikidata
View/Edit Human	View/Edit Mouse

CSF2RB (also known as cytokine receptor common subunit beta) is a common subunit to the following type I cytokine receptors:

References

GRCh38: Ensembl release 89: ENSG00000100368 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000071714 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". The EMBO Journal. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

External links

Cytokine+Receptor+Common+beta+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: P32927 (Human Cytokine receptor common subunit beta (CSF2RB)) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100368 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071714 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Woodcock_1994-5] Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". The EMBO Journal. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

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