CRIPT

CRIPT
Identifiers
Aliases	CRIPT, SSMDF, HSPC139, CXXC repeat containing interactor of PDZ3 domain
External IDs	OMIM: 604594; MGI: 1929655; HomoloGene: 8572; GeneCards: CRIPT; OMA:CRIPT - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	46,630,176 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	87,343,238 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; corpus epididymis; ; caput epididymis; ; tail of epididymis; ; cerebellar vermis; ; internal globus pallidus; ; superficial temporal artery; ; visceral pleura; ; buccal mucosa cell; ; trabecular bone;
	Top expressed in
	zygote; ; spermatocyte; ; spermatid; ; medial ganglionic eminence; ; endocardial cushion; ; Epithelium of choroid plexus; ; seminal vesicula; ; blood; ; facial motor nucleus; ; anterior horn of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; scaffold protein binding; PDZ domain binding; protein binding; protein-containing complex binding;
Cellular component	cytoplasm; dendritic shaft; cell junction; soma; dendritic spine; dendrite; cell projection; synapse; nucleolus; postsynaptic density; nucleus; fibrillar center;
Biological process	regulation of postsynaptic density protein 95 clustering; protein localization to microtubule; cytoplasmic microtubule organization; establishment of protein localization;
	Sources:Amigo / QuickGO
Orthologs
	9419
	56724
	ENSG00000119878
	ENSMUSG00000024146
	Q9P021
	O70333
	NM_014171
	NM_019936
	NP_054890
	NP_064320
	Wikidata
View/Edit Human	View/Edit Mouse

Cysteine-rich PDZ-binding protein is a protein that in humans is encoded by the CRIPT gene.⁵⁶⁷⁸⁹

Interactions

CRIPT has been shown to interact with DLG3.¹⁰

References

GRCh38: Ensembl release 89: ENSG00000119878 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024146 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Fukunaga Y, Matsubara M, Nagai R, Miyazawa A (Aug 2005). "The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins". J Biochem. 138 (2): 177–82. doi:10.1093/jb/mvi107. PMID 16091592.
Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF (Feb 2002). "The PDZ1 domain of SAP90. Characterization of structure and binding". J Biol Chem. 277 (9): 6967–73. doi:10.1074/jbc.M109453200. PMID 11744724.
Passafaro M, Sala C, Niethammer M, Sheng M (Jan 2000). "Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95". Nat Neurosci. 2 (12): 1063–9. doi:10.1038/15990. PMID 10570482. S2CID 8145832.
Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Jun 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron. 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762. S2CID 16068361.
"Entrez Gene: CRIPT cysteine-rich PDZ-binding protein".
Lim, Indra Adi; Hall Duane D; Hell Johannes W (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24). United States: 21697–711. doi:10.1074/jbc.M112339200. ISSN 0021-9258. PMID 11937501.

External links

Human CRIPT genome location and CRIPT gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119878 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024146 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16091592-5] Fukunaga Y, Matsubara M, Nagai R, Miyazawa A (Aug 2005). "The interaction between PSD-95 and Ca2+/calmodulin is enhanced by PDZ-binding proteins". J Biochem. 138 (2): 177–82. doi:10.1093/jb/mvi107. PMID 16091592.

[pmid11744724-6] Piserchio A, Pellegrini M, Mehta S, Blackman SM, Garcia EP, Marshall J, Mierke DF (Feb 2002). "The PDZ1 domain of SAP90. Characterization of structure and binding". J Biol Chem. 277 (9): 6967–73. doi:10.1074/jbc.M109453200. PMID 11744724.

[pmid10570482-7] Passafaro M, Sala C, Niethammer M, Sheng M (Jan 2000). "Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95". Nat Neurosci. 2 (12): 1063–9. doi:10.1038/15990. PMID 10570482. S2CID 8145832.

[pmid9581762-8] Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Jun 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron. 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762. S2CID 16068361.

[entrez-9] "Entrez Gene: CRIPT cysteine-rich PDZ-binding protein".

[pmid11937501-10] Lim, Indra Adi; Hall Duane D; Hell Johannes W (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". J. Biol. Chem. 277 (24). United States: 21697–711. doi:10.1074/jbc.M112339200. ISSN 0021-9258. PMID 11937501.

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Interactions

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Further reading

External links