CREB3

CREB3
Identifiers
Aliases	CREB3, LUMAN, LZIP, sLZIP, cAMP responsive element binding protein 3
External IDs	OMIM: 606443; MGI: 99946; HomoloGene: 31375; GeneCards: CREB3; OMA:CREB3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)1 Band 9p13.3 Start 35,732,598 bp1 End 35,736,999 bp1
Gene location (Mouse) Chr. Chromosome 4 (mouse)2 Band 4 A5|4 23.05 cM Start 43,562,332 bp2 End 43,567,060 bp2
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right testis popliteal artery tibial arteries ascending aorta left testis Descending thoracic aorta right adrenal gland left adrenal gland left adrenal cortex Top expressed in ascending aorta aortic valve Paneth cell Epithelium of choroid plexus supraoptic nucleus calvaria substantia nigra endothelial cell of lymphatic vessel pituitary gland facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein homodimerization activity protein dimerization activity cAMP response element binding protein binding DNA-binding transcription factor activity CCR1 chemokine receptor binding DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding protein binding cAMP response element binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm integral component of membrane nuclear body endoplasmic reticulum membrane membrane integral component of endoplasmic reticulum membrane soma endoplasmic reticulum nucleus cytosol Golgi membrane nucleoplasm Golgi apparatus Biological process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of transcription, DNA-templated release from viral latency positive regulation of cell migration cytoplasmic sequestering of transcription factor negative regulation of cell cycle positive regulation of monocyte chemotaxis transcription, DNA-templated response to endoplasmic reticulum stress induction of positive chemotaxis positive regulation of transcription, DNA-templated chemotaxis response to unfolded protein regulation of cell population proliferation regulation of cell growth establishment of viral latency positive regulation of deacetylase activity positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response viral process positive regulation of transcription by RNA polymerase II positive regulation of defense response to virus by host positive regulation of calcium ion transport transcription by RNA polymerase II endoplasmic reticulum unfolded protein response regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10488 12913 Ensembl ENSG00000107175 ENSMUSG00000028466 UniProt O43889 Q61817 RefSeq (mRNA) NM_006368 NM_013497 RefSeq (protein) NP_006359 n/a Location (UCSC) Chr 9: 35.73 – 35.74 Mb Chr 4: 43.56 – 43.57 Mb PubMed search 3 4
Wikidata
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Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.⁵⁶

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.⁶

CREB3 has been shown to interact with Host cell factor C1.⁷⁸