CPSF3

CPSF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I7T, 2I7V
Identifiers
Aliases	CPSF3, CPSF-73, CPSF73, cleavage and polyadenylation specific factor 3
External IDs	OMIM: 606029; MGI: 1859328; HomoloGene: 6499; GeneCards: CPSF3; OMA:CPSF3 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	9,473,101 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	21,365,057 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; left testis; ; right testis; ; endothelial cell; ; tendon of biceps brachii; ; sperm; ; monocyte; ; stromal cell of endometrium; ; islet of Langerhans;
	Top expressed in
	primitive streak; ; medullary collecting duct; ; ureter; ; internal carotid artery; ; condyle; ; fossa; ; vas deferens; ; Epithelium of choroid plexus; ; external carotid artery; ; endothelial cell of lymphatic vessel;
	More reference expression data
	n/a
Gene ontology
Molecular function	5'-3' exonuclease activity; metal ion binding; endoribonuclease activity; protein binding; RNA binding; nuclease activity; endonuclease activity; hydrolase activity;
Cellular component	mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm; nucleus;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA 3'-end processing by stem-loop binding and cleavage; mRNA processing; mRNA export from nucleus; mRNA polyadenylation; mRNA cleavage; mRNA 3'-end processing; RNA phosphodiester bond hydrolysis, endonucleolytic; sno(s)RNA 3'-end processing; snoRNA splicing; pre-mRNA cleavage required for polyadenylation;
	Sources:Amigo / QuickGO
Orthologs
	51692
	54451
	ENSG00000119203
	ENSMUSG00000054309
	Q9UKF6
	Q9QXK7
	NM_016207; NM_001321833; NM_001321834; NM_001321835; NM_001321836
	NM_018813; NM_001364372; NM_001364373
	NP_001308762; NP_001308763; NP_001308764; NP_001308765; NP_057291
	NP_061283; NP_001351301; NP_001351302
	Wikidata
View/Edit Human	View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000119203 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000054309 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jenny A, Minvielle-Sebastia L, Preker PJ, Keller W (Dec 1996). "Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I". Science. 274 (5292): 1514–7. Bibcode:1996Sci...274.1514J. doi:10.1126/science.274.5292.1514. PMID 8929409. S2CID 12958377.
"Entrez Gene: CPSF3 cleavage and polyadenylation specific factor 3, 73kDa".

External links

Human CPSF3 genome location and CPSF3 gene details page in the UCSC Genome Browser.

Further reading

Murthy KG, Manley JL (1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.
Jenny A, Hauri HP, Keller W (1994). "Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit". Mol. Cell. Biol. 14 (12): 8183–90. doi:10.1128/MCB.14.12.8183. PMC 359357. PMID 7969155.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Thuresson AC, Aström J, Aström A, et al. (1994). "Multiple forms of poly(A) polymerases in human cells". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 979–83. Bibcode:1994PNAS...91..979T. doi:10.1073/pnas.91.3.979. PMC 521437. PMID 8302877.
McCracken S, Fong N, Yankulov K, et al. (1997). "The C-terminal domain of RNA polymerase II couples mRNA processing to transcription". Nature. 385 (6614): 357–61. Bibcode:1997Natur.385..357M. doi:10.1038/385357a0. PMID 9002523. S2CID 4307073.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Takagaki Y, Manley JL (2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. PMC 85326. PMID 10669729.
de Vries H, Rüegsegger U, Hübner W, et al. (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kaufmann I, Martin G, Friedlein A, et al. (2005). "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase". EMBO J. 23 (3): 616–26. doi:10.1038/sj.emboj.7600070. PMC 1271804. PMID 14749727.
Calzado MA, Sancho R, Muñoz E (2004). "Human immunodeficiency virus type 1 Tat increases the expression of cleavage and polyadenylation specificity factor 73-kilodalton subunit modulating cellular and viral expression". J. Virol. 78 (13): 6846–54. doi:10.1128/JVI.78.13.6846-6854.2004. PMC 421638. PMID 15194760.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mandel CR, Kaneko S, Zhang H, et al. (2007). "Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease". Nature. 444 (7121): 953–6. doi:10.1038/nature05363. PMC 3866582. PMID 17128255.
de la Vega L, Sánchez-Duffhues G, Fresno M, et al. (2007). "The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein". J. Mol. Biol. 372 (2): 317–30. doi:10.1016/j.jmb.2007.06.075. PMID 17669424.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119203 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054309 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8929409-5] Jenny A, Minvielle-Sebastia L, Preker PJ, Keller W (Dec 1996). "Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I". Science. 274 (5292): 1514–7. Bibcode:1996Sci...274.1514J. doi:10.1126/science.274.5292.1514. PMID 8929409. S2CID 12958377.

[entrez-6] "Entrez Gene: CPSF3 cleavage and polyadenylation specific factor 3, 73kDa".

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