Article · Wikipedia archive · Last revised Jun 19, 2026

CPD-1

CPD-1 (LS-193743) is a drug with a benzofuranyl piperazine structure, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity and full agonist efficacy at the 5-HT2C subtype, and lower affinity and partial agonist action at the 5-HT2A and 5-HT2B subtypes.

Last revised
Jun 19, 2026
Read time
≈ 1 min
Length
165 w
Citations
2
Source
Wikipedia ↗
CPD-1
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • (3S)-3-Methyl-1-[4-(trifluoromethyl)-1-benzofuran-7-yl]piperazine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H15F3N2O
Molar mass284.282 g·mol−1
3D model (JSmol)
  • C[C@H]1CN(CCN1)C2=C3C(=C(C=C2)C(F)(F)F)C=CO3
  • InChI=1S/C14H15F3N2O/c1-9-8-19(6-5-18-9)12-3-2-11(14(15,16)17)10-4-7-20-13(10)12/h2-4,7,9,18H,5-6,8H2,1H3/t9-/m0/s1
  • Key:RZSIBGYUCGYDKG-VIFPVBQESA-N

CPD-1 (LS-193743) is a drug with a benzofuranyl piperazine structure, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity and full agonist efficacy at the 5-HT2C subtype, and lower affinity and partial agonist action at the 5-HT2A and 5-HT2B subtypes.12

See also

See also

References

References

  1. Ahmed A, Choo H, Cho YS, Park WK, Pae AN (July 2009). "Identification of novel serotonin 2C receptor ligands by sequential virtual screening". Bioorganic & Medicinal Chemistry. 17 (13): 4559–68. doi:10.1016/j.bmc.2009.05.003. PMID 19464901.
  2. Rodriguez MM, Overshiner C, Leander JD, Li X, Morrow D, Conway RG, et al. (2017). "Behavioral Effects of a Novel Benzofuranyl-Piperazine Serotonin-2C Receptor Agonist Suggest a Potential Therapeutic Application in the Treatment of Obsessive-Compulsive Disorder". Frontiers in Psychiatry. 8 89. doi:10.3389/fpsyt.2017.00089. PMC 5438973. PMID 28588509.