Codoxime

Codoxime
Clinical data
Other names	Codoxime
ATC code	none;
Legal status
Legal status	BR: Class A1 (Narcotic drugs); CA: Schedule I; DE: Anlage I (Authorized scientific use only); UN: Narcotic Schedule I;
Identifiers
	IUPAC name (((4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-ylidene)amino)oxy)acetic acid;
CAS Number	7125-76-0;
PubChem CID	9570253;
ChemSpider	7844721;
UNII	JT5I2F57F7;
KEGG	D03581;
ChEMBL	ChEMBL2107300;
ECHA InfoCard	100.027.660
Chemical and physical data
Formula	C20H24N2O5
Molar mass	372.421 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)CO\N=C4\[C@@H]5Oc1c2c(ccc1OC)C[C@H]3N(CC[C@]25[C@H]3CC4)C;

Codoxime (Codossima) is an opiate analogue that is a derivative of hydrocodone, where the 6-ketone group has been replaced by carboxymethyloxime. It has primarily antitussive effects² and was found to have moderate potential to cause dependence in animal studies.³

References

Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
US granted 3153042, Jack Fishman, "Morphinone and Codeinone Derivatives", issued 13 October 1964, assigned to Mozes Juda Lowenstein
Jasinski DR, Martin WR (1967). "Assessment of the dependence-producing properties of dihydrocodeinone and codoxime". Clinical Pharmacology and Therapeutics. 8 (2): 266–70. doi:10.1002/cpt196782266. PMID 6021586. S2CID 36504901.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] US granted 3153042, Jack Fishman, "Morphinone and Codeinone Derivatives", issued 13 October 1964, assigned to Mozes Juda Lowenstein

[pmid6021586-3] Jasinski DR, Martin WR (1967). "Assessment of the dependence-producing properties of dihydrocodeinone and codoxime". Clinical Pharmacology and Therapeutics. 8 (2): 266–70. doi:10.1002/cpt196782266. PMID 6021586. S2CID 36504901.

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