Article · Wikipedia archive · Last revised Jun 17, 2026

Cod-THC

Cod-THC is a synthetic codrug formed by linking tetrahydrocannabinol with codeine via a carbonate bridge. It is well absorbed orally and shows superior analgesic effects in animal studies compared to a simple mixture of the two drugs.

Last revised
Jun 17, 2026
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Cod-THC
Identifiers
  • [(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] [(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-yl] carbonate
PubChem CID
Chemical and physical data
FormulaC40H49NO6
Molar mass639.833 g·mol−1
3D model (JSmol)
  • CN1CC[C@@]23c4c5C[C@@H]1[C@@H]2C=C[C@H](OC(=O)Oc1cc(CCCCC)cc2OC(C)(C)[C@@H]6CCC(C)=C[C@H]6c21)[C@@H]3Oc4c(OC)cc5
  • InChI=InChI=1S/C40H49NO6/c1-7-8-9-10-24-20-32(34-26-19-23(2)11-13-27(26)39(3,4)47-33(34)21-24)45-38(42)44-31-16-14-28-29-22-25-12-15-30(43-6)36-35(25)40(28,37(31)46-36)17-18-41(29)5/h12,14-16,19-21,26-29,31,37H,7-11,13,17-18,22H2,1-6H3/t26-,27-,28+,29-,31+,37+,40+/m1/s1
  • Key:VDTVNOCXWSYPQX-IWHNUUHWSA-N

Cod-THC (Codeine Δ9-tetrahydrocannabinol carbonate) is a synthetic codrug formed by linking tetrahydrocannabinol with codeine via a carbonate bridge. It is well absorbed orally and shows superior analgesic effects in animal studies compared to a simple mixture of the two drugs.123

THC can partially inhibit CYP2D6, which is the enzyme that transforms codeine into its active metabolite morphine.45 It's not well understood how THC may impact codeines metabolism in humans.

See also

See also

References

References

  1. Banerjee A, Hayward JJ, Trant JF (May 2023). ""Breaking bud": the effect of direct chemical modifications of phytocannabinoids on their bioavailability, physiological effects, and therapeutic potential". Organic & Biomolecular Chemistry. 21 (18): 3715–3732. doi:10.1039/d3ob00068k. PMID 36825573.
  2. US 2008176885A1, Holtman JR, Crooks PA, Dhooper HK, "Novel synergistic opioid-cannabinoid codrug for pain management", published 24 July 2008, assigned to University of Kentucky and Insys Therapeutics Inc 
  3. Crooks PA, Dhooper HK, Chakraborty U (2010). "Improving the Use of Drug Combinations Through the Codrug Approach". Prodrugs and Targeted Delivery. Methods and Principles in Medicinal Chemistry. Vol. 47. pp. 345–383. doi:10.1002/9783527633166.ch13. ISBN 978-3-527-32603-7.
  4. Nasrin S, Watson CJ, Perez-Paramo YX, Lazarus P (December 2021). "Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions". Drug Metabolism and Disposition. 49 (12): 1070–1080. doi:10.1124/dmd.121.000442. PMC 11022895. PMID 34493602.
  5. Huff HC, Vasan A, Roy P, Kaul A, Tajkhorshid E, Das A (September 2021). "Differential Interactions of Selected Phytocannabinoids with Human CYP2D6 Polymorphisms". Biochemistry. 60 (37): 2749–2760. doi:10.1021/acs.biochem.1c00158. PMC 8455456. PMID 34491040.