CNOT6L

CNOT6L
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3NGN, 3NGO, 3NGQ, 5DV2
Identifiers
Aliases	CNOT6L, CCR4b, CCR4-NOT transcription complex subunit 6 like
External IDs	OMIM: 618069; MGI: 2443154; HomoloGene: 100830; GeneCards: CNOT6L; OMA:CNOT6L - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	77,819,615 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	96,312,030 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; mucosa of ileum; ; superficial temporal artery; ; tibialis anterior muscle; ; bone marrow cell; ; thymus; ; corpus epididymis; ; tonsil; ; jejunal mucosa; ; epithelium of colon;
	Top expressed in
	hair follicle; ; skin of external ear; ; Rostral migratory stream; ; secondary oocyte; ; primary oocyte; ; vas deferens; ; utricle; ; efferent ductule; ; blood; ; tibiofemoral joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	poly(A)-specific ribonuclease activity; metal ion binding; protein binding; nuclease activity; exonuclease activity; hydrolase activity; 3'-5'-exoribonuclease activity;
Cellular component	cytoplasm; CCR4-NOT complex; nucleus; cytosol;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; regulation of transcription, DNA-templated; RNA phosphodiester bond hydrolysis, exonucleolytic; mRNA processing; transcription, DNA-templated; positive regulation of cytoplasmic mRNA processing body assembly; mRNA destabilization; positive regulation of cell population proliferation; gene silencing; regulation of translation; nucleic acid phosphodiester bond hydrolysis; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
	Sources:Amigo / QuickGO
Orthologs
	246175
	231464
	ENSG00000138767
	ENSMUSG00000034724
	Q96LI5
	Q8VEG6
	NM_001286790; NM_144571; NM_001365006; NM_001365007
	NM_001285511; NM_001285514; NM_144910; NM_178854
	NP_001273719; NP_653172; NP_001351935; NP_001351936
	NP_001272440; NP_001272443; NP_659159; NP_849185
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 6 like is a protein that in humans is encoded by the CNOT6L gene.⁵ It is a paralog of CNOT6 and therefore a potential subunit of the CCR4-Not deadenylase complex.

References

GRCh38: Ensembl release 89: ENSG00000138767 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034724 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: CCR4-NOT transcription complex subunit 6 like". Retrieved 2020-04-15.

Further reading

Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T (July 2007). "Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth". Mol. Cell. Biol. 27 (13): 4980–90. doi:10.1128/MCB.02304-06. PMC 1951489. PMID 17452450.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J, Ito K, Wang Q, Zhao C, Bartlam M, Yamamoto T, Rao Z (August 2010). "Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity". EMBO J. 29 (15): 2566–76. doi:10.1038/emboj.2010.152. PMC 2928688. PMID 20628353.
Naylor MG, Weiss ST, Lange C (September 2010). "A Bayesian approach to genetic association studies with family-based designs". Genet. Epidemiol. 34 (6): 569–74. doi:10.1002/gepi.20513. PMC 3349938. PMID 20818722.
Mittal S, Aslam A, Doidge R, Medica R, Winkler GS (March 2011). "The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence". Mol. Biol. Cell. 22 (6): 748–58. doi:10.1091/mbc.E10-11-0898. PMC 3057700. PMID 21233283.
Zhou W, Thiery JP (June 2013). "Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1". J. Cell Sci. 126 (Pt 12): 2740–6. doi:10.1242/jcs.126367. PMID 23591815.
Polesskaya A, Pinna G, Sassi Y, Vandamme M, Bigot A, Mouly V, Morozova N, Harel-Bellan A, Degerny C (February 2016). "Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation". Biochim. Biophys. Acta. 1863 (2): 263–70. doi:10.1016/j.bbamcr.2015.11.018. PMID 26608607.
Zhang Q, Yan D, Guo E, Ding B, Yang W, Liu R, Yamamoto T, Bartlam M (April 2016). "Structural basis for inhibition of the deadenylase activity of human CNOT6L". FEBS Lett. 590 (8): 1270–9. doi:10.1002/1873-3468.12160. PMID 27013054.
Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N (April 2019). "Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis". Proc. Natl. Acad. Sci. U.S.A. 116 (16): 7973–7981. doi:10.1073/pnas.1816023116. PMC 6475422. PMID 30926667.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138767 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034724 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CCR4-NOT transcription complex subunit 6 like". Retrieved 2020-04-15.

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