CNOT4

CNOT4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E4U, 1UR6
Identifiers
Aliases	CNOT4, CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4
External IDs	OMIM: 604911; MGI: 1859026; HomoloGene: 40870; GeneCards: CNOT4; OMA:CNOT4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	135,510,127 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	35,110,659 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Achilles tendon; ; testicle; ; gastrocnemius muscle; ; parietal pleura; ; corpus callosum; ; internal globus pallidus; ; sural nerve; ; endothelial cell; ; muscle of thigh;
	Top expressed in
	genital tubercle; ; Rostral migratory stream; ; tail of embryo; ; zygote; ; saccule; ; primary oocyte; ; secondary oocyte; ; otic placode; ; fossa; ; otic vesicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; nucleic acid binding; metal ion binding; transferase activity; RNA binding;
Cellular component	cytosol; cytoplasm; CCR4-NOT complex; nucleus;
Biological process	protein ubiquitination; nuclear-transcribed mRNA poly(A) tail shortening; protein autoubiquitination; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; ubiquitin-dependent protein catabolic process; regulation of megakaryocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	4850
	53621
	ENSG00000080802
	ENSMUSG00000038784
	O95628
	Q8BT14
NM_001008225; NM_001190847; NM_001190848; NM_001190849; NM_001190850;
	NM_013316; NM_001393370; NM_001393371; NM_001393372; NM_001393373; NM_001393374; NM_001393375
	NM_001164411; NM_001164412; NM_001164413; NM_001164414; NM_016877
NP_001008226; NP_001177776; NP_001177777; NP_001177778; NP_001177779;
	NP_037448
	NP_001157883; NP_001157884; NP_001157885; NP_001157886; NP_058573
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.⁵

Function

The protein encoded by this gene is a subunit of the CCR4-Not complex, a global transcriptional regulator and deadenylase. The encoded protein interacts with CNOT1 and has ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]. Diseases associated with CNOT4 include Adenoiditis.⁶

References

GRCh38: Ensembl release 89: ENSG00000080802 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038784 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: CCR4-NOT transcription complex, subunit 4".
"CNOT4 Gene - GeneCards | CNOT4 Protein | CNOT4 Antibody". www.genecards.org. Retrieved 2019-06-21.

Further reading

Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M (March 2012). "Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells". FASEB Journal. 26 (3): 1239–50. doi:10.1096/fj.11-195875. PMID 22159038. S2CID 25618632.
Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT (March 2004). "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair". Journal of Molecular Biology. 337 (1): 157–65. doi:10.1016/j.jmb.2004.01.031. PMID 15001359.
Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT (September 2009). "Human Ccr4-Not complexes contain variable deadenylase subunits" (PDF). The Biochemical Journal. 422 (3): 443–53. doi:10.1042/BJ20090500. PMID 19558367.
Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT (February 2002). "Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex". The EMBO Journal. 21 (3): 355–64. doi:10.1093/emboj/21.3.355. PMC 125831. PMID 11823428.
Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R (April 2004). "Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches". Structure. 12 (4): 633–44. doi:10.1016/j.str.2004.03.004. PMID 15062086.
Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (June 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD (April 2009). "Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression". Genes & Development. 23 (8): 951–62. doi:10.1101/gad.1769209. PMC 2675863. PMID 19346402.
Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R (March 2001). "The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers". The Journal of Biological Chemistry. 276 (13): 10185–90. doi:10.1074/jbc.M009298200. PMID 11087754.
Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Research. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000080802 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038784 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CCR4-NOT transcription complex, subunit 4".

[6] "CNOT4 Gene - GeneCards | CNOT4 Protein | CNOT4 Antibody". www.genecards.org. Retrieved 2019-06-21.

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