CNOT2

CNOT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4C0D, 4C0F, 5FU6, 5FU7
Identifiers
Aliases	CNOT2, CDC36, NOT2, NOT2H, HSPC131, CCR4-NOT transcription complex subunit 2, IDNADFS
External IDs	OMIM: 604909; MGI: 1919318; HomoloGene: 40953; GeneCards: CNOT2; OMA:CNOT2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	70,354,993 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	116,417,416 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; Achilles tendon; ; nipple; ; epithelium of nasopharynx; ; human penis; ; epithelium of colon; ; ganglionic eminence; ; skin of abdomen; ; cerebellar cortex;
	Top expressed in
	genital tubercle; ; ciliary body; ; internal carotid artery; ; external carotid artery; ; medullary collecting duct; ; iris; ; tail of embryo; ; primitive streak; ; retinal pigment epithelium; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	poly(A)-specific ribonuclease activity; transcription coregulator activity; protein binding;
Cellular component	cytoplasm; membrane; CCR4-NOT complex; P-body; CCR4-NOT core complex; nucleus; cytosol; plasma membrane;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of translation; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; regulation of stem cell population maintenance; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; positive regulation of cytoplasmic mRNA processing body assembly; trophectodermal cell differentiation; gene silencing; negative regulation of intracellular estrogen receptor signaling pathway; regulation of translation; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA phosphodiester bond hydrolysis, exonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	4848
	72068
	ENSG00000111596
	ENSMUSG00000020166
	Q9NZN8
	Q8C5L3
	NM_001199302; NM_001199303; NM_014515
NM_001037846; NM_001037847; NM_001037848; NM_028082; NM_001359247;
	NM_001359248; NM_001359249; NM_001359250; NM_001359251; NM_001359252; NM_001359253; NM_001359563
	NP_001186231; NP_001186232; NP_055330
NP_001032935; NP_001032936; NP_001032937; NP_082358; NP_001346176;
	NP_001346177; NP_001346178; NP_001346179; NP_001346180; NP_001346181; NP_001346182; NP_001346492
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 2 is a protein that in humans is encoded by the CNOT2 gene.⁵⁶ It is a subunit of the CCR4-Not deadenylase complex.

References

GRCh38: Ensembl release 89: ENSG00000111596 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020166 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (Mar 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
"Entrez Gene: CNOT2 CCR4-NOT transcription complex, subunit 2".

External links

Human CNOT2 genome location and CNOT2 gene details page in the UCSC Genome Browser.

Further reading

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zwartjes CG, Jayne S, van den Berg DL, Timmers HT (2004). "Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex". J. Biol. Chem. 279 (12): 10848–54. doi:10.1074/jbc.M311747200. PMID 14707134.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Shi J, Nelson MA (2005). "The cyclin-dependent kinase 11 interacts with NOT2". Biochem. Biophys. Res. Commun. 334 (4): 1310–6. doi:10.1016/j.bbrc.2005.07.026. PMID 16039607.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Jayne S, Zwartjes CG, van Schaik FM, Timmers HT (2006). "Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex". Biochem. J. 398 (3): 461–7. doi:10.1042/BJ20060406. PMC 1559471. PMID 16712523.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111596 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020166 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10637334-5] Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (Mar 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

[entrez-6] "Entrez Gene: CNOT2 CCR4-NOT transcription complex, subunit 2".

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