Article · Wikipedia archive · Last revised Jul 6, 2026

Clobenpropit

Clobenpropit is a histamine H3 receptor antagonist. It has neuroprotective effects via stimulation of GABA release in brain cells in vitro.

Last revised
Jul 6, 2026
Read time
≈ 1 min
Length
135 w
Citations
2
Source
Wikipedia ↗
Clobenpropit
Clinical data
ATC code
  • None
Legal status
Legal status
Identifiers
  • N'-[(4-chlorophenyl)methyl]-1-[3-(3H-imidazol-4-yl)propylsulfanyl]formamidine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H17ClN4S
Molar mass308.83 g·mol−1
3D model (JSmol)
  • C1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl

Clobenpropit is a histamine H3 receptor antagonist.1 It has neuroprotective effects via stimulation of GABA release in brain cells in vitro.2

References

References

  1. Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". European Journal of Pharmacology. 567 (3): 206–210. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431.
  2. Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z (2007). "The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons". European Journal of Pharmacology. 563 (1–3): 117–123. doi:10.1016/j.ejphar.2007.01.069. PMID 17350613.