CHMP4C

CHMP4C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3C3R
Identifiers
Aliases	CHMP4C, SNF7-3, Shax3, VPS32C, charged multivesicular body protein 4C
External IDs	OMIM: 610899; MGI: 1913621; HomoloGene: 23544; GeneCards: CHMP4C; OMA:CHMP4C - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	81,759,515 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	10,493,916 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; jejunal mucosa; ; mucosa of ileum; ; skin of arm; ; palpebral conjunctiva; ; parotid gland; ; duodenum; ; pancreatic epithelial cell; ; gingival epithelium; ; mucosa of colon;
	Top expressed in
	interventricular septum; ; ileum; ; duodenum; ; jejunum; ; epithelium of stomach; ; Paneth cell; ; left colon; ; ascending aorta; ; parotid gland; ; epithelium of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding;
Cellular component	cytoplasm; ESCRT III complex; cytosol; endosome; membrane; late endosome membrane; midbody; Flemming body;
Biological process	regulation of centrosome duplication; abscission; viral budding via host ESCRT complex; viral life cycle; nucleus organization; multivesicular body assembly; regulation of mitotic spindle assembly; endosomal transport; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway; protein transport; negative regulation of cytokinesis; septum digestion after cytokinesis; mitotic metaphase plate congression; vacuolar transport; macroautophagy; mitotic cytokinesis checkpoint signaling; midbody abscission;
	Sources:Amigo / QuickGO
Orthologs
	92421
	66371
	ENSG00000164695
	ENSMUSG00000027536
	Q96CF2
	Q9D7F7
	NM_152284
	NM_025519
	NP_689497
	NP_079795
	Wikidata
View/Edit Human	View/Edit Mouse

Charged multivesicular body protein 4c is a protein that in humans is encoded by the CHMP4C gene.⁵⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000164695 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027536 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M (Sep 2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J Biol Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.
Katoh K, Shibata H, Hatta K, Maki M (Dec 2003). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch Biochem Biophys. 421 (1): 159–65. doi:10.1016/j.abb.2003.09.038. PMID 14678797.
"Entrez Gene: CHMP4C chromatin modifying protein 4C".

External links

Human CHMP4C genome location and CHMP4C gene details page in the UCSC Genome Browser.

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164695 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027536 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12860994-5] Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M (Sep 2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J Biol Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.

[pmid14678797-6] Katoh K, Shibata H, Hatta K, Maki M (Dec 2003). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch Biochem Biophys. 421 (1): 159–65. doi:10.1016/j.abb.2003.09.038. PMID 14678797.

[entrez-7] "Entrez Gene: CHMP4C chromatin modifying protein 4C".

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