CHL1

CHL1
Identifiers
Aliases	CHL1, CALL, L1CAM2, cell adhesion molecule L1 like
External IDs	OMIM: 607416; MGI: 1098266; HomoloGene: 21314; GeneCards: CHL1; OMA:CHL1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	409,417 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	103,727,172 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; superior frontal gyrus; ; sural nerve; ; spinal ganglia; ; postcentral gyrus; ; frontal pole; ; Brodmann area 10; ; trigeminal ganglion; ; middle temporal gyrus;
	Top expressed in
	spermatid; ; subiculum; ; ventral tegmental area; ; lobe of cerebellum; ; lateral hypothalamus; ; dorsomedial hypothalamic nucleus; ; supraoptic nucleus; ; substantia nigra; ; cerebellar vermis; ; ventromedial nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protease binding;
Cellular component	integral component of membrane; membrane; plasma membrane; apical part of cell; extracellular region; dendrite; extracellular exosome;
Biological process	negative regulation of neuron apoptotic process; cell differentiation; cognition; axon regeneration; adult locomotory behavior; neuron migration; nervous system development; multicellular organism development; cell adhesion; exploration behavior; neuron projection development; signal transduction; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	10752
	12661
	ENSG00000134121
	ENSMUSG00000030077
	O00533
	P70232
	NM_001253387; NM_001253388; NM_006614
	NM_007697
	NP_001240316; NP_001240317; NP_006605
	NP_031723
	Wikidata
View/Edit Human	View/Edit Mouse

Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene.⁶

CHL1 is a cell adhesion molecule closely related to the L1. In melanocytic cells CHL1 gene expression may be regulated by MITF,⁷ and can act as a helicase protein during the interphase stage of mitosis.

The protein, however, has dynamic localisation, meaning that it has not only multiple roles in the cell, but also various locations.

References

GRCh38: Ensembl release 89: ENSG00000134121 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030077 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Pandey G, Kanwar P, Pandey A (2014). Global Comparative Analysis of CBL-CIPK Gene Families in Plants. Springer International Publishing. p. 52. ISBN 978-3-319-09078-8.
Wei MH, Karavanova I, Ivanov SV, Popescu NC, Keck CL, Pack S, et al. (September 1998). "In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules". Human Genetics. 103 (3): 355–364. doi:10.1007/s004390050829. PMID 9799093. S2CID 3177127.
Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–676. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

External links

CHL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CHL1 genome location and CHL1 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134121 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030077 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Pandey-5] Pandey G, Kanwar P, Pandey A (2014). Global Comparative Analysis of CBL-CIPK Gene Families in Plants. Springer International Publishing. p. 52. ISBN 978-3-319-09078-8.

[pmid9799093-6] Wei MH, Karavanova I, Ivanov SV, Popescu NC, Keck CL, Pack S, et al. (September 1998). "In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules". Human Genetics. 103 (3): 355–364. doi:10.1007/s004390050829. PMID 9799093. S2CID 3177127.

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–676. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

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