CHD5

CHD5
Identifiers
Aliases	CHD5, CHD-5, chromodomain helicase DNA binding protein 5, PMNDS
External IDs	OMIM: 610771; MGI: 3036258; HomoloGene: 56712; GeneCards: CHD5; OMA:CHD5 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	6,180,321 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	152,474,651 bp
RNA expression pattern
	Top expressed in
	sperm; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; Brodmann area 10; ; Brodmann area 9; ; pituitary gland; ; left testis; ; right testis; ; primary visual cortex;
	Top expressed in
	subiculum; ; central gray substance of midbrain; ; dorsal tegmental nucleus; ; cingulate gyrus; ; visual cortex; ; habenula; ; lateral hypothalamus; ; primary visual cortex; ; medial vestibular nucleus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; helicase activity; metal ion binding; H3K27me3 modified histone binding; hydrolase activity; ATP binding;
Cellular component	NuRD complex; membrane; heterochromatin; nucleus; nucleoplasm; cytosol; nuclear speck;
Biological process	cell differentiation; regulation of transcription, DNA-templated; histone H3-K27 trimethylation; positive regulation of signal transduction by p53 class mediator; transcription, DNA-templated; nervous system development; spermatogenesis; histone H4 acetylation; cerebral cortex neuron differentiation; negative regulation of cell population proliferation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	26038
	269610
	ENSG00000116254
	ENSMUSG00000005045
	Q8TDI0
	A2A8L1
	NM_015557
	NM_001081376; NM_029216; NM_001369243
	NP_056372
	NP_001074845; NP_083492; NP_001356172
	Wikidata
View/Edit Human	View/Edit Mouse

Chromodomain-helicase-DNA-binding protein 5 is an enzyme that in humans is encoded by the CHD5 gene.⁵⁶⁷ It is a part of the CHD subfamily of ATP-dependent chromatin remodeling complexes.

References

GRCh38: Ensembl release 89: ENSG00000116254 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000005045 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases". Mamm Genome. 13 (2): 117–9. doi:10.1007/s00335-001-3042-6. PMID 11889561. S2CID 1694959.
Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003). "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system". Oncogene. 22 (7): 1002–11. doi:10.1038/sj.onc.1206211. PMID 12592387.
"Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5".

External links

Human CHD5 genome location and CHD5 gene details page in the UCSC Genome Browser.

Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Bagchi A, Papazoglu C, Wu Y, et al. (2007). "CHD5 is a tumor suppressor at human 1p36". Cell. 128 (3): 459–75. doi:10.1016/j.cell.2006.11.052. PMID 17289567. S2CID 13437928.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116254 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005045 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11889561-5] Schuster EF, Stoger R (Mar 2002). "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases". Mamm Genome. 13 (2): 117–9. doi:10.1007/s00335-001-3042-6. PMID 11889561. S2CID 1694959.

[pmid12592387-6] Thompson PM, Gotoh T, Kok M, White PS, Brodeur GM (Feb 2003). "CHD5, a new member of the chromodomain gene family, is preferentially expressed in the nervous system". Oncogene. 22 (7): 1002–11. doi:10.1038/sj.onc.1206211. PMID 12592387.

[entrez-7] "Entrez Gene: CHD5 chromodomain helicase DNA binding protein 5".

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