Article · Wikipedia archive · Last revised Jun 18, 2026

CF3-Etomidate

CF3-Etomidate (TF-Etomidate) is an anesthetic drug related to etomidate, which has been sold as a designer drug as an active ingredient in e-cigarette liquids marketed under names such as space oil or kpods. It has a trifluoroethyl ester group in place of the ethyl ester of etomidate.

Last revised
Jun 18, 2026
Read time
≈ 1 min
Length
154 w
Citations
3
Source
Wikipedia ↗
CF3-Etomidate
Identifiers
  • 2,2,2-trifluoroethyl 3-[1-phenylethyl]imidazole-4-carboxylate
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC14H13F3N2O2
Molar mass298.265 g·mol−1
3D model (JSmol)
  • CC(C1=CC=CC=C1)N2C=NC=C2C(=O)OCC(F)(F)F
  • InChI=1S/C14H13F3N2O2/c1-10(11-5-3-2-4-6-11)19-9-18-7-12(19)13(20)21-8-14(15,16)17/h2-7,9-10H,8H2,1H3
  • Key:SKSDRVNGIZFJOJ-UHFFFAOYSA-N

CF3-Etomidate (TF-Etomidate) is an anesthetic drug related to etomidate, which has been sold as a designer drug as an active ingredient in e-cigarette liquids marketed under names such as space oil or kpods. It has a trifluoroethyl ester group in place of the ethyl ester of etomidate.123

References

References

  1. Fan Y, Chen X, Wu H, Ke X, Chen H, Xu Y, et al. (November 2025). "Leveraging mass spectrometry fragmentation patterns for accelerated screening and structural elucidation of new etomidate analogues in suspect samples". Journal of Pharmaceutical and Biomedical Analysis. 265 117023. doi:10.1016/j.jpba.2025.117023. PMID 40532400.
  2. Zhang X, Li Y, Liu J, Pan Z, Chen Y, Wang M, et al. (July 2025). "Identification of two novel imidazole-derived GABA agonists butomidate and tf-etomidate in e-cigarette liquids". Forensic Toxicology. doi:10.1007/s11419-025-00732-5. PMID 40643820.
  3. "CF3-etomidate". UNODC Laboratory and Scientific Service Portals.