CDH6

CDH6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LND
Identifiers
Aliases	CDH6, CAD6, KCAD, cadherin 6
External IDs	OMIM: 603007; MGI: 107435; HomoloGene: 21027; GeneCards: CDH6; OMA:CDH6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)1 Band 5p13.3 Start 31,193,686 bp1 End 31,329,146 bp1
Gene location (Mouse) Chr. Chromosome 15 (mouse)2 Band 15|15 A1 Start 13,028,787 bp2 End 13,173,761 bp2
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell kidney tubule tibial arteries human kidney endothelial cell vena cava gallbladder sural nerve lateral nuclear group of thalamus metanephric glomerulus Top expressed in internal carotid artery external carotid artery hair follicle ascending aorta aortic valve Rostral migratory stream renal corpuscle efferent ductule ciliary body iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component integral component of membrane plasma membrane membrane cell surface catenin complex Biological process Notch signaling pathway cell adhesion adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell-cell adhesion cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1004 12563 Ensembl ENSG00000113361 ENSMUSG00000039385 UniProt P55285 P97326 RefSeq (mRNA) NM_004932 NM_001362435 NM_007666 RefSeq (protein) NP_004923 NP_001349364 NP_031692 Location (UCSC) Chr 5: 31.19 – 31.33 Mb Chr 15: 13.03 – 13.17 Mb PubMed search 3 4
Wikidata
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Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.⁵⁶⁷

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.⁷