IGSF8

IGSF8
Identifiers
Aliases	IGSF8, CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8
External IDs	OMIM: 606644; MGI: 2154090; HomoloGene: 14163; GeneCards: IGSF8; OMA:IGSF8 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,098,943 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	172,147,408 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; C1 segment; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; putamen; ; hypothalamus; ; nucleus accumbens;
	Top expressed in
	ventricular zone; ; primary visual cortex; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; perirhinal cortex; ; superior colliculus; ; respiratory epithelium; ; nasal epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular exosome; membrane; integral component of membrane; plasma membrane;
Biological process	skeletal muscle tissue development; nervous system development; cell population proliferation; single fertilization; cell motility;
	Sources:Amigo / QuickGO
Orthologs
	93185
	140559
	ENSG00000162729
	ENSMUSG00000038034
	Q969P0
	Q8R366
	NM_001206665; NM_052868; NM_001320247
	NM_080419
	NP_001193594; NP_001307176; NP_443100
	NP_536344
	Wikidata
View/Edit Human	View/Edit Mouse

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.⁵⁶⁷ IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells.⁸ IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor).⁸ IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer,⁸ and has been proposed as a potential therapeutic target in gliomas.⁹ In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.⁸

Cancer biomarker

In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker.⁹ IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.¹⁰

References

GRCh38: Ensembl release 89: ENSG00000162729 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038034 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem. 276 (44): 40545–40554. doi:10.1074/jbc.M107338200. PMID 11504738.
Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol. 167 (9): 5115–5121. doi:10.4049/jimmunol.167.9.5115. PMID 11673522.
"Entrez Gene: IGSF8 immunoglobulin superfamily, member 8".
Li Y, Wu X, Sheng C, Liu H, Liu H, Tang Y, et al. (May 2024). "IGSF8 is an innate immune checkpoint and cancer immunotherapy target". Cell. 187 (11): 2703–2716.e23. doi:10.1016/j.cell.2024.03.039. ISSN 0092-8674. PMID 38657602.
Ren J, Huang P, Wang F (September 2024). "IGSF8 is a potential target for the treatment of gliomas". Asian Journal of Surgery. 47 (9): 3883–3891. doi:10.1016/j.asjsur.2024.02.118. PMID 38453613.
Trinidad CV, Pathak HB, Cheng S, Tzeng S, Madan R, Sardiu ME, et al. (2023-10-26). "Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer". Scientific Reports. 13 (1) 18341. Bibcode:2023NatSR..1318341T. doi:10.1038/s41598-023-44050-5. ISSN 2045-2322. PMC 10603107. PMID 37884576.

External links

IGSF8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162729 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038034 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11504738-5] Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem. 276 (44): 40545–40554. doi:10.1074/jbc.M107338200. PMID 11504738.

[pmid11673522-6] Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol. 167 (9): 5115–5121. doi:10.4049/jimmunol.167.9.5115. PMID 11673522.

[entrez-7] "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8".

[:0-8] Li Y, Wu X, Sheng C, Liu H, Liu H, Tang Y, et al. (May 2024). "IGSF8 is an innate immune checkpoint and cancer immunotherapy target". Cell. 187 (11): 2703–2716.e23. doi:10.1016/j.cell.2024.03.039. ISSN 0092-8674. PMID 38657602.

[:1-9] Ren J, Huang P, Wang F (September 2024). "IGSF8 is a potential target for the treatment of gliomas". Asian Journal of Surgery. 47 (9): 3883–3891. doi:10.1016/j.asjsur.2024.02.118. PMID 38453613.

[10] Trinidad CV, Pathak HB, Cheng S, Tzeng S, Madan R, Sardiu ME, et al. (2023-10-26). "Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer". Scientific Reports. 13 (1) 18341. Bibcode:2023NatSR..1318341T. doi:10.1038/s41598-023-44050-5. ISSN 2045-2322. PMC 10603107. PMID 37884576.

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Cancer biomarker

References

Further reading

External links