CD180

CD180
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B2D
Identifiers
Aliases	CD180, LY64, Ly78, RP105, CD180 molecule
External IDs	OMIM: 602226; MGI: 1194924; HomoloGene: 4077; GeneCards: CD180; OMA:CD180 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	67,196,799 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	102,876,137 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; lymph node; ; white blood cell; ; monocyte; ; granulocyte; ; spleen; ; appendix; ; bone marrow cell; ; blood; ; superficial temporal artery;
	Top expressed in
	mesenteric lymph nodes; ; zygote; ; granulocyte; ; secondary oocyte; ; spleen; ; primary oocyte; ; right ventricle; ; tibiofemoral joint; ; blood; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; extracellular space; extracellular matrix;
Biological process	positive regulation of lipopolysaccharide-mediated signaling pathway; innate immune response; cellular response to lipopolysaccharide; B cell proliferation involved in immune response; immune system process; toll-like receptor signaling pathway; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	4064
	17079
	ENSG00000134061
	ENSMUSG00000021624
	Q99467
	Q62192
	NM_005582
	NM_008533; NM_001360519
	NP_005573
	NP_032559; NP_001347448
	Wikidata
View/Edit Human	View/Edit Mouse

CD180 antigen is a protein that in humans is encoded by the CD180 gene.⁵⁶⁷⁸

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. CD180 is expressed on antigen presenting cells including B cells and dendritic cells. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.⁷

Recently, CD180 has been demonstrated to be involved in the survival and prognosis of B-cell chronic lymphocytic leukemia.⁹¹⁰

References

GRCh38: Ensembl release 89: ENSG00000134061 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021624 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, et al. (Nov 1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood. 92 (8): 2815–2822. doi:10.1182/blood.V92.8.2815. PMID 9763566.
Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, et al. (Mar 1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics. 38 (3): 299–304. doi:10.1006/geno.1996.0632. PMID 8975706.
"Entrez Gene: CD180 CD180 molecule".
[4]
Porakishvili N, Memon A, Vispute K, Kulikova N, Clark EA, Rai KR, et al. (May 2011). "CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells". British Journal of Haematology. 153 (4): 486–498. doi:10.1111/j.1365-2141.2011.08605.x. ISSN 0007-1048. PMID 21443749. S2CID 13360804.
Gordiienko I, Shlapatska L, Kholodniuk V, Sklyarenko L, Gluzman DF, Clark EA, et al. (2017-10-05). "The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling". PLOS ONE. 12 (10) e0185940. Bibcode:2017PLoSO..1285940G. doi:10.1371/journal.pone.0185940. ISSN 1932-6203. PMC 5628907. PMID 28982149.

External links

Human CD180 genome location and CD180 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q99467 (Human CD180 antigen) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q62192 (Mouse CD180 antigen) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134061 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021624 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9763566-5] Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, et al. (Nov 1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood. 92 (8): 2815–2822. doi:10.1182/blood.V92.8.2815. PMID 9763566.

[pmid8975706-6] Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, et al. (Mar 1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics. 38 (3): 299–304. doi:10.1006/geno.1996.0632. PMID 8975706.

[entrez-7] "Entrez Gene: CD180 CD180 molecule".

[8] [4]

[9] Porakishvili N, Memon A, Vispute K, Kulikova N, Clark EA, Rai KR, et al. (May 2011). "CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells". British Journal of Haematology. 153 (4): 486–498. doi:10.1111/j.1365-2141.2011.08605.x. ISSN 0007-1048. PMID 21443749. S2CID 13360804.

[10] Gordiienko I, Shlapatska L, Kholodniuk V, Sklyarenko L, Gluzman DF, Clark EA, et al. (2017-10-05). "The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling". PLOS ONE. 12 (10) e0185940. Bibcode:2017PLoSO..1285940G. doi:10.1371/journal.pone.0185940. ISSN 1932-6203. PMC 5628907. PMID 28982149.

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