CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .56
CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.5
CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.
See also
See also
References
References
Further reading
Further reading
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- Ugarova TP, Yakubenko VP (2001). "Recognition of fibrinogen by leukocyte integrins". Ann. N. Y. Acad. Sci. 936 (1): 368–85. Bibcode:2001NYASA.936..368U. doi:10.1111/j.1749-6632.2001.tb03523.x. PMID 11460493. S2CID 44753700.
- Valentin A, Lundin K, Patarroyo M, Asjö B (1990). "The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells". J. Immunol. 144 (3): 934–7. doi:10.4049/jimmunol.144.3.934. PMID 1967280.
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- Corbi AL, Garcia-Aguilar J, Springer TA (1990). "Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule". J. Biol. Chem. 265 (5): 2782–8. doi:10.1016/S0021-9258(19)39870-9. PMID 2303426.
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- Corbi AL, Miller LJ, O'Connor K, et al. (1988). "cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95". EMBO J. 6 (13): 4023–8. doi:10.1002/j.1460-2075.1987.tb02746.x. PMC 553883. PMID 3327687.
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- Bilsland CA, Diamond MS, Springer TA (1994). "The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain". J. Immunol. 152 (9): 4582–9. doi:10.4049/jimmunol.152.9.4582. PMID 7512600.
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- de Vree WJ, Fontijne-Dorsman AN, Koster JF, Sluiter W (1996). "Photodynamic treatment of human endothelial cells promotes the adherence of neutrophils in vitro". Br. J. Cancer. 73 (11): 1335–40. doi:10.1038/bjc.1996.255. PMC 2074486. PMID 8645576.
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- Shelley CS, Da Silva N, Georgakis A, et al. (1998). "Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb". Genomics. 49 (2): 334–6. doi:10.1006/geno.1998.5232. PMID 9598326.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
