CCNB1IP1

CCNB1IP1
Identifiers
Aliases	CCNB1IP1, C14orf18, HEI10, cyclin B1 interacting protein 1
External IDs	OMIM: 608249; MGI: 2685134; HomoloGene: 18819; GeneCards: CCNB1IP1; OMA:CCNB1IP1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	20,333,312 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	51,045,189 bp
RNA expression pattern
	Top expressed in
	left ovary; ; ganglionic eminence; ; right ovary; ; gastric mucosa; ; cartilage tissue; ; ventricular zone; ; body of uterus; ; apex of heart; ; right auricle of heart; ; left ventricle;
	Top expressed in
	epiblast; ; fetal liver hematopoietic progenitor cell; ; embryo; ; morula; ; spermatocyte; ; primitive streak; ; embryo; ; blastocyst; ; otic placode; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin protein ligase activity; transferase activity;
Cellular component	condensed nuclear chromosome; synaptonemal complex; nucleus; chromosome;
Biological process	reciprocal meiotic recombination; chiasma assembly; meiosis; blastocyst formation; protein ubiquitination; spermatid development;
	Sources:Amigo / QuickGO
Orthologs
	57820
	239083
	ENSG00000100814
	ENSMUSG00000071470
	Q9NPC3
	D3Z3K2
	NM_182852; NM_021178; NM_182849; NM_182851
	NM_001111119
	NP_067001; NP_878269; NP_878272
	NP_001104589
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene.⁵⁶

HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM]⁶ It is considered a housekeeping gene.

During meiosis, crossing over between homologous chromosomes (homologs) facilitates accurate chromosome segregation.⁷ In mammals, the ring-domain protein CCNB1IP1, also known as HEI10, promotes crossing over between each pair of homologs during meiosis.⁷ Studies in the mouse showed that this pro-crossover ring-domain protein facilitates the homologous recombination and DNA repair processes that produce crossovers.⁷

References

GRCh38: Ensembl release 89: ENSG00000100814 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000071470 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Toby GG, Gherraby W, Coleman TR, Golemis EA (Mar 2003). "A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels". Mol Cell Biol. 23 (6): 2109–2122. doi:10.1128/MCB.23.6.2109-2122.2003. PMC 149478. PMID 12612082.
"Entrez Gene: CCNB1IP1 cyclin B1 interacting protein 1".
Ito M, Yun Y, Kulkarni DS, Lee S, Sandhu S, Nuñez B, Hu L, Lee K, Lim N, Hirota RM, Prendergast R, Huang C, Huang I, Hunter N (January 2025). "Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis". Proc Natl Acad Sci U S A. 122 (2) e2412961121. doi:10.1073/pnas.2412961121. PMC 11745341. PMID 39761402.

External links

Human CCNB1IP1 genome location and CCNB1IP1 gene details page in the UCSC Genome Browser.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–828. doi:10.1101/gr.6.9.807. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Grönholm M, Muranen T, Toby GG, et al. (2006). "A functional association between merlin and HEI10, a cell cycle regulator". Oncogene. 25 (32): 4389–4398. doi:10.1038/sj.onc.1209475. PMID 16532029.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100814 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071470 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12612082-5] Toby GG, Gherraby W, Coleman TR, Golemis EA (Mar 2003). "A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels". Mol Cell Biol. 23 (6): 2109–2122. doi:10.1128/MCB.23.6.2109-2122.2003. PMC 149478. PMID 12612082.

[entrez-6] "Entrez Gene: CCNB1IP1 cyclin B1 interacting protein 1".

[Ito2025-7] Ito M, Yun Y, Kulkarni DS, Lee S, Sandhu S, Nuñez B, Hu L, Lee K, Lim N, Hirota RM, Prendergast R, Huang C, Huang I, Hunter N (January 2025). "Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis". Proc Natl Acad Sci U S A. 122 (2) e2412961121. doi:10.1073/pnas.2412961121. PMC 11745341. PMID 39761402.

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