CBLC

CBLC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OP0, 3VRN, 3VRO, 3VRP, 3VRQ, 3VRR
Identifiers
Aliases	CBLC, CBL-3, CBL-SL, RNF57, Cbl proto-oncogene C
External IDs	OMIM: 608453; MGI: 1931457; HomoloGene: 8108; GeneCards: CBLC; OMA:CBLC - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,800,652 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,530,734 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; skin of abdomen; ; skin of leg; ; duodenum; ; right lobe of liver; ; body of pancreas; ; jejunal mucosa; ; rectum; ; olfactory zone of nasal mucosa; ; minor salivary glands;
	Top expressed in
	duodenum; ; intestinal villus; ; right kidney; ; epithelium of stomach; ; jejunum; ; lip; ; proximal tubule; ; colon; ; esophagus; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; phosphotyrosine residue binding; calcium ion binding; epidermal growth factor receptor binding; ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; transferase activity; receptor tyrosine kinase binding; zinc ion binding; protein binding;
Cellular component	plasma membrane; membrane raft;
Biological process	negative regulation of epidermal growth factor-activated receptor activity; cell surface receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; protein ubiquitination; regulation of signaling; ubiquitin-dependent protein catabolic process; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23624
	80794
	ENSG00000142273
	ENSMUSG00000040525
	Q9ULV8
	Q80XL1
	NM_001130852; NM_012116
	NM_001161844; NM_023224
	NP_001124324; NP_036248
	NP_001155316; NP_075713
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.⁵⁶⁷

CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]⁷

Interactions

CBLC has been shown to interact with FYN⁸ and Epidermal growth factor receptor.⁶⁹

References

GRCh38: Ensembl release 89: ENSG00000142273 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040525 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. PMID 10362357. S2CID 28195948.
Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Dec 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. PMID 10571044.
"Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c".
Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Oct 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1). NETHERLANDS: 145–54. doi:10.1016/S0378-1119(99)00356-X. ISSN 0378-1119. PMID 10571044.
Keane MM, Ettenberg S A, Nau M M, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22). ENGLAND: 3365–75. doi:10.1038/sj.onc.1202753. ISSN 0950-9232. PMID 10362357. S2CID 28195948.

External links

Human CBLC genome location and CBLC gene details page in the UCSC Genome Browser.

Further reading

Ollendorff V, Mattei M, Fournier E, et al. (1999). "A third human CBL gene is on chromosome 19". Int. J. Oncol. 13 (6): 1159–61. doi:10.3892/ijo.13.6.1159. PMID 9824625.
Irby RB, Mao W, Coppola D, et al. (1999). "Activating SRC mutation in a subset of advanced human colon cancers". Nat. Genet. 21 (2): 187–90. doi:10.1038/5971. PMID 9988270. S2CID 27129630.
Ettenberg SA, Keane MM, Nau MM, et al. (1999). "Cbl-b inhibits epidermal growth factor receptor signaling". Oncogene. 18 (10): 1855–66. doi:10.1038/sj.onc.1202499. PMID 10086340.
Loreto MP, Berry DM, McGlade CJ (2002). "Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling". Mol. Cell. Biol. 22 (12): 4241–55. doi:10.1128/MCB.22.12.4241-4255.2002. PMC 133880. PMID 12024036.
Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
Courbard JR, Fiore F, Adélaïde J, et al. (2003). "Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH". J. Biol. Chem. 277 (47): 45267–75. doi:10.1074/jbc.M206460200. PMID 12226085.
Wong ES, Fong CW, Lim J, et al. (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. doi:10.1093/emboj/cdf493. PMC 126289. PMID 12234920.
Taher TE, Tjin EP, Beuling EA, et al. (2002). "C-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination". J. Immunol. 169 (7): 3793–800. doi:10.4049/jimmunol.169.7.3793. PMID 12244174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nau MM, Lipkowitz S (2003). "Comparative genomic organization of the cbl genes". Gene. 308: 103–13. doi:10.1016/S0378-1119(03)00471-2. PMID 12711395.
Kim M, Tezuka T, Tanaka K, Yamamoto T (2004). "Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation". Oncogene. 23 (9): 1645–55. doi:10.1038/sj.onc.1207298. PMID 14661060. S2CID 24925646.
Kassenbrock CK, Anderson SM (2004). "Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations". J. Biol. Chem. 279 (27): 28017–27. doi:10.1074/jbc.M404114200. PMID 15117950.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142273 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040525 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10362357-5] Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22): 3365–75. doi:10.1038/sj.onc.1202753. PMID 10362357. S2CID 28195948.

[pmid10571044-6] Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Dec 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1): 145–54. doi:10.1016/S0378-1119(99)00356-X. PMID 10571044.

[entrez-7] "Entrez Gene: CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c".

[autogenerated2-8] Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Oct 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1). NETHERLANDS: 145–54. doi:10.1016/S0378-1119(99)00356-X. ISSN 0378-1119. PMID 10571044.

[autogenerated1-9] Keane MM, Ettenberg S A, Nau M M, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22). ENGLAND: 3365–75. doi:10.1038/sj.onc.1202753. ISSN 0950-9232. PMID 10362357. S2CID 28195948.

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