CARD10

CARD10
Identifiers
Aliases	CARD10, BIMP1, CARMA3, caspase recruitment domain family member 10, IMD89
External IDs	OMIM: 607209; MGI: 2146012; HomoloGene: 8728; GeneCards: CARD10; OMA:CARD10 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,519,542 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,687,242 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; jejunal mucosa; ; pancreatic ductal cell; ; sural nerve; ; duodenum; ; glomerulus; ; apex of heart; ; metanephric glomerulus; ; mucosa of transverse colon; ; mucosa of ileum;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; granulocyte; ; ventral tegmental area; ; motor neuron; ; vestibular membrane of cochlear duct; ; pontine nuclei; ; sciatic nerve; ; renal corpuscle; ; human kidney; ; utricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor complex adaptor activity; protein binding; CARD domain binding;
Cellular component	cytoplasm; CBM complex;
Biological process	regulation of apoptotic process; activation of NF-kappaB-inducing kinase activity; negative regulation of cell migration involved in sprouting angiogenesis; positive regulation of protein localization to nucleus; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	29775
	105844
	ENSG00000100065
	ENSMUSG00000033170
	Q9BWT7
	P58660
	NM_014550
	NM_130859
	NP_055365
	NP_570929
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase recruitment domain-containing protein 10 is a protein in the CARD-CC protein family that in humans is encoded by the CARD10 gene.⁵⁶⁷

Function

The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (NF-κB; MIM 164011) activity through the IKK (e.g., IKBKB; MIM 603258) complex. CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.[supplied by OMIM]⁷

Interactions

CARD10 has been shown to interact with BCL10.⁸

References

GRCh38: Ensembl release 89: ENSG00000100065 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000033170 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.
"Entrez Gene: CARD10 caspase recruitment domain family, member 10".
Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.

External links

Human CARD10 genome location and CARD10 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100065 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033170 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11259443-5] Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.

[pmid11356195-6] Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.

[entrez-7] "Entrez Gene: CARD10 caspase recruitment domain family, member 10".

[autogenerated1-8] Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.

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Function

Interactions

References

Further reading

External links