Canio is a name. Notable people with this name include:
- Canio of Atella, also known as San Canio and Saint Canius
- Cristián Canío (born 1981), Chilean football player
- Luigi De Canio (born 1957), Italian football player
- Paolo Di Canio (born 1968), Italian football player
- Virgilio Canio Corbo (1918–1991), Italian friar
Fictional characters
- Canio, from the opera Pagliacci