| CAMK4 |
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| Identifiers |
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| Aliases | CAMK4, CaMK IV, CaMK-GR, IV, caMK, calcium/calmodulin-dependent protein kinase IV, calcium/calmodulin dependent protein kinase IV, CaMKIV |
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| External IDs | OMIM: 114080; MGI: 88258; HomoloGene: 100780; GeneCards: CAMK4; OMA:CAMK4 - orthologs |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 18 (mouse)2 |
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| | Band | 18 B1|18 18.15 cM | Start | 33,067,984 bp2 |
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| End | 33,324,281 bp2 |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - cerebellar vermis
- cerebellar hemisphere
- right hemisphere of cerebellum
- middle temporal gyrus
- left testis
- right testis
- paraflocculus of cerebellum
- ganglionic eminence
- nucleus accumbens
- superior frontal gyrus
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| | Top expressed in | - cerebellar cortex
- superior frontal gyrus
- thymus
- primary visual cortex
- lobe of cerebellum
- seminiferous tubule
- dentate gyrus of hippocampal formation granule cell
- cerebellar vermis
- spermatid
- olfactory tubercle
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| | More reference expression data |
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| BioGPS | |
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| Wikidata |
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Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.5
The product of this gene belongs to the serine/threonine protein kinase cluster, and to the Ca2+/calmodulin-dependent protein kinase (CAMK) group. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.6
References
References
Further reading
Further reading
- Bredt DS, Ferris CD, Snyder SH (1992). "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. doi:10.1016/S0021-9258(19)49862-1. PMID 1375933.
- Jensen KF, Ohmstede CA, Fisher RS, Sahyoun N (1991). "Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2850–3. Bibcode:1991PNAS...88.2850J. doi:10.1073/pnas.88.7.2850. PMC 51337. PMID 2011593.
- Selbert MA, Anderson KA, Huang QH, et al. (1995). "Phosphorylation and activation of Ca2+-calmodulin-dependent protein kinase IV by Ca2+-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation". J. Biol. Chem. 270 (29): 17616–21. doi:10.1074/jbc.270.29.17616. PMID 7615569.
- Kitani T, Okuno S, Fujisawa H (1994). "cDNA cloning and expression of human calmodulin-dependent protein kinase IV". J. Biochem. 115 (4): 637–40. doi:10.1093/oxfordjournals.jbchem.a124387. PMID 8089075.
- Mosialos G, Hanissian SH, Jawahar S, et al. (1994). "A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1". J. Virol. 68 (3): 1697–705. doi:10.1128/JVI.68.3.1697-1705.1994. PMC 236629. PMID 8107230.
- Bland MM, Monroe RS, Ohmstede CA (1994). "The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus". Gene. 142 (2): 191–7. doi:10.1016/0378-1119(94)90260-7. PMID 8194751.
- Tokumitsu H, Soderling TR (1996). "Requirements for calcium and calmodulin in the calmodulin kinase activation cascade". J. Biol. Chem. 271 (10): 5617–22. doi:10.1074/jbc.271.10.5617. PMID 8621423.
- Chatila T, Anderson KA, Ho N, Means AR (1996). "A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR". J. Biol. Chem. 271 (35): 21542–8. doi:10.1074/jbc.271.35.21542. PMID 8702940.
- Melander Gradin H, Marklund U, Larsson N, et al. (1997). "Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18". Mol. Cell. Biol. 17 (6): 3459–67. doi:10.1128/mcb.17.6.3459. PMC 232199. PMID 9154845.
- Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. doi:10.1074/jbc.273.34.21473. PMID 9705275.
- Anderson KA, Means RL, Huang QH, et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. doi:10.1074/jbc.273.48.31880. PMID 9822657.
- Hayashi Y, Nishio M, Naito Y, et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597–602. doi:10.1074/jbc.274.29.20597. PMID 10400690.
- Blaeser F, Ho N, Prywes R, Chatila TA (2000). "Ca2+-dependent gene expression mediated by MEF2 transcription factors". J. Biol. Chem. 275 (1): 197–209. doi:10.1074/jbc.275.1.197. PMID 10617605.
- Moreno CS, Park S, Nelson K, et al. (2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–63. doi:10.1074/jbc.275.8.5257. PMC 3505218. PMID 10681496.
- Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells". J. Biol. Chem. 275 (36): 28139–43. doi:10.1074/jbc.M003198200. PMID 10874031.
- Wu JY, Ribar TJ, Cummings DE, et al. (2000). "Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4". Nat. Genet. 25 (4): 448–52. doi:10.1038/78153. PMID 10932193. S2CID 10803791.
- Jang MK, Goo YH, Sohn YC, et al. (2001). "Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit". J. Biol. Chem. 276 (23): 20005–10. doi:10.1074/jbc.M010211200. PMID 11274168.
- Hsu LS, Chen GD, Lee LS, et al. (2001). "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. doi:10.1074/jbc.M011720200. PMID 11395482.
- Zhao X, Ito A, Kane CD, et al. (2001). "The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking". J. Biol. Chem. 276 (37): 35042–8. doi:10.1074/jbc.M105086200. PMID 11470791.
- Ainhoa Bilbaoa; Jan Rodriguez Parkitnab; David Engblomb; Stéphanie Perreau-Lenza; Carles Sanchis-Seguraa; Miriam Schneidera; Witold Konopkab; Magdalena Westphalb; Gerome Breenc; Sylvane Desrivieresc; Matthias Klugmannd; Camila Guindalinie; Homero Valladag; Ronaldo Laranjeirae; Fernando Rodriguez de Fonsecah; Gunter Schumannc; Günther Schützb & Rainer Spanagela (2008). "Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine". Proceedings of the National Academy of Sciences of the United States of America. 105 (45). PNAS: 17549–54. Bibcode:2008PNAS..10517549B. doi:10.1073/pnas.0803959105. PMC 2582267. PMID 19001277.
- Feliciano DM, Edelman AM (2009). "Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells". J. Biol. Chem. 284 (39): 26466–81. doi:10.1074/jbc.M109.027680. PMC 2785335. PMID 19633294.
External links
External links
