Article · Wikipedia archive · Last revised Jun 30, 2026

Calphostin

The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides. The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity.

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The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides.12 The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC).12 The most potent member of the series, calphostin C,1 has found use as a biochemical tool because of this activity.3

Calpohostin R1 R2
Calphostin A Bz Bz
Calphostin B Bz H
Calphostin C Bz 4-(HO)Bz
Calphostin D H H
Calphostin I 4-(HO)Bz 4-(HO)Bz

Calphostin C

Calphostin C is a potent inhibitor of protein kinase C (PKC).123

References

References

  1. Kobayashi, E; Ando, K; Nakano, H; Iida, T; Ohno, H; Morimoto, M; Tamaoki, T (1989). "Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities". Journal of Antibiotics. 42 (10): 1470–1474. doi:10.7164/antibiotics.42.1470. PMID 2478514.
  2. Iida, T; Kobayashi, E; Yoshida, M; Sano, H (1989). "Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures". Journal of Antibiotics. 42 (10): 1475–1481. doi:10.7164/antibiotics.42.1475. PMID 2478515.
  3. "Calphostin C". Biomol GmbH. Retrieved 11 October 2024.
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