Article · Wikipedia archive · Last revised Jun 12, 2026

4-Oxo-2-nonenal

4-Oxo-2-nonenal is a lipid peroxidation product that can structurally alter proteins and induce α-synuclein oligomers.

Last revised
Jun 12, 2026
Read time
≈ 1 min
Length
125 w
Citations
1
Source
Wikipedia ↗
4-Oxo-2-nonenal
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Names
Preferred IUPAC name
(2E)-4-Oxonon-2-enal
Identifiers
3D model (JSmol)
4963551
ChEBI
ChEMBL
ChemSpider
  • InChI=1S/C9H14O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-8H,2-4,6H2,1H3/b7-5+ COPY
    Key: SEPPVOUBHWNCAW-FNORWQNLSA-N
  • CCCCCC(=O)/C=C/C=O
Properties
C9H14O2
Molar mass 154.209 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

4-Oxo-2-nonenal is a lipid peroxidation product that can structurally alter proteins and induce α-synuclein oligomers.1

References

References

  1. Näsström, Thomas; Fagerqvist, Therese; Barbu, Mikael; et al. (2011). "The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties". Free Radical Biology and Medicine. 50 (3): 428–437. doi:10.1016/j.freeradbiomed.2010.11.027. PMID 21130160.