Article · Wikipedia archive · Last revised Jun 14, 2026

Bufanolide

Bufanolide is a C24 steroid and, indirectly, a parent structure of bufadienolide. Its derivatives was found in Bufo and Scilla, as an aglycone of cardiac glycosides and is usually toxic.

Last revised
Jun 14, 2026
Read time
≈ 1 min
Length
157 w
Citations
1
Source
Wikipedia ↗
Bufanolide
source ↗
Names
IUPAC name
5ξ-Bufanolide
Systematic IUPAC name
(5R)-5-[(1R,3aR,3bR,5aΞ,9aS,9bS,11aS)-9a,11a-Dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]oxan-2-one
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C24H38O2/c1-23-13-4-3-5-17(23)7-8-18-20-10-9-19(16-6-11-22(25)26-15-16)24(20,2)14-12-21(18)23/h16-21H,3-15H2,1-2H3/t16-,17?,18-,19+,20+,21-,23-,24+/m0/s1
    Key: PXOHOSHERMSUCD-YQMMVUDVSA-N
  • CC12CCCCC1CCC3C2CCC4(C3CCC4C5CCC(=O)OC5)C
  • C[C@]12CC[C@H]3[C@H]([C@H]1CC[C@@H]2[C@H]4CCC(=O)OC4)CCC5[C@@]3(CCCC5)C
Properties
C24H38O2
Molar mass 358.28718
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Bufanolide is a C24 steroid and, indirectly, a parent structure of bufadienolide. Its derivatives was found in Bufo and Scilla, as an aglycone of cardiac glycosides and is usually toxic.1

References

References

  1. Tao Song, Yuanyuan Zhang, Qiongtao Song, Xue Han, Shengjiang Guan, Xuan Zhang, Xi Chu, Fenghua Zhang, Jianping Zhang, Li Chu (2017-08-16). "Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K + currents expressed in HEK293 cells". Fundamental & Clinical Pharmacology. 31 (6): 695–700. doi:10.1111/fcp.12306. PMID 28755515. S2CID 1094461.{{cite journal}}: CS1 maint: multiple names: authors list (link)