Article · Wikipedia archive · Last revised Jul 8, 2026

BHFF

BHFF is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor. It has anxiolytic effects in animal studies, and good oral bioavailability.

Last revised
Jul 8, 2026
Read time
≈ 1 min
Length
109 w
Citations
1
Source
Wikipedia ↗
BHFF
Identifiers
  • 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.229.838
Chemical and physical data
FormulaC17H21F3O3
Molar mass330.347 g·mol−1
3D model (JSmol)
  • FC(F)(F)C2(O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1OC2=O
  • InChI=1S/C17H21F3O3/c1-14(2,3)9-7-10(15(4,5)6)12-11(8-9)16(22,13(21)23-12)17(18,19)20/h7-8,22H,1-6H3 checkY
  • Key:RVNOANDLZIIFHB-UHFFFAOYSA-N checkY
  (verify)

BHFF is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor. It has anxiolytic effects in animal studies, and good oral bioavailability.1

References

References

  1. Malherbe P, Masciadri R, Norcross RD, Knoflach F, Kratzeisen C, Zenner MT, et al. (June 2008). "Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors". British Journal of Pharmacology. 154 (4): 797–811. doi:10.1038/bjp.2008.135. PMC 2439845. PMID 18536733.
External links
  • Media related to BHFF at Wikimedia Commons