Article · Wikipedia archive · Last revised Jun 11, 2026

BAZ1A

Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene.

Last revised
Jun 11, 2026
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Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene.12

Structure

The protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs:1

Function

BAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.34

The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent.4 Furthermore, the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin.5

Interactions

BAZ1A has been shown to interact with SMARCA534678 and SATB1.7

References

References

  1. Jones MH, Hamana N, Nezu J, Shimane M (Apr 2000). "A novel family of bromodomain genes". Genomics. 63 (1): 40–5. doi:10.1006/geno.1999.6071. PMID 10662543.
  2. "Entrez Gene: BAZ1A bromodomain adjacent to zinc finger domain, 1A".
  3. Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R (February 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1038–43. Bibcode:2000PNAS...97.1038B. doi:10.1073/pnas.97.3.1038. PMC 15513. PMID 10655480.
  4. Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (July 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
  5. Collins N, Poot RA, Kukimoto I, García-Jiménez C, Dellaire G, Varga-Weisz PD (December 2002). "An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin". Nat. Genet. 32 (4): 627–32. doi:10.1038/ng1046. PMID 12434153. S2CID 22545162.
  6. Bozhenok, Ludmila; Wade Paul A; Varga-Weisz Patrick (May 2002). "WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci". EMBO J. 21 (9). England: 2231–41. doi:10.1093/emboj/21.9.2231. ISSN 0261-4189. PMC 125993. PMID 11980720.
  7. Yasui, Dag; Miyano Masaru; Cai Shutao; Varga-Weisz Patrick; Kohwi-Shigematsu Terumi (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907). England: 641–5. Bibcode:2002Natur.419..641Y. doi:10.1038/nature01084. ISSN 0028-0836. PMID 12374985. S2CID 25822700.
  8. Hakimi, Mohamed-Ali; Bochar Daniel A; Schmiesing John A; Dong Yuanshu; Barak Orr G; Speicher David W; Yokomori Kyoko; Shiekhattar Ramin (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature. 418 (6901). England: 994–8. Bibcode:2002Natur.418..994H. doi:10.1038/nature01024. ISSN 0028-0836. PMID 12198550. S2CID 4344470.