AUP1

AUP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EKF
Identifiers
Aliases	AUP1, ancient ubiquitous protein 1, lipid droplet regulating VLDL assembly factor, AUP1 lipid droplet regulating VLDL assembly factor
External IDs	OMIM: 602434; MGI: 107789; HomoloGene: 7239; GeneCards: AUP1; OMA:AUP1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,529,760 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,034,789 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; body of pancreas; ; mucosa of transverse colon; ; body of stomach; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; tendon of biceps brachii; ; spleen; ; right lobe of liver; ; minor salivary glands;
	Top expressed in
	right kidney; ; granulocyte; ; muscle of thigh; ; proximal tubule; ; choroid plexus of fourth ventricle; ; yolk sac; ; neural layer of retina; ; lip; ; superior frontal gyrus; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin binding; ubiquitin-protein transferase activator activity; protein binding;
Cellular component	extracellular exosome; endoplasmic reticulum membrane; membrane; integral component of endoplasmic reticulum membrane; Hrd1p ubiquitin ligase ERAD-L complex; integral component of membrane; endoplasmic reticulum;
Biological process	retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway; regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	550
	11993
	ENSG00000115307
	ENSMUSG00000068328
	Q9Y679
	P70295
	NM_181575
	NM_001025446; NM_001301649; NM_007517
	NP_853553
	NP_001288578; NP_031543
	Wikidata
View/Edit Human	View/Edit Mouse

Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.⁵⁶⁷

Function

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha (IIb) subunits. These subunits play a crucial role in the integrin alpha (IIb) beta (3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.⁷

Interactions

AUP1 has been shown to interact with ITGA2B.⁶

References

GRCh38: Ensembl release 89: ENSG00000115307 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000068328 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jang W, Weber JS, Bashir R, Bushby K, Meisler MH (Jan 1997). "Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13". Genomics. 36 (2): 366–8. doi:10.1006/geno.1996.0477. PMID 8812468.
Kato A, Kawamata N, Tamayose K, Egashira M, Miura R, Fujimura T, Murayama K, Oshimi K (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J Biol Chem. 277 (32): 28934–41. doi:10.1074/jbc.M204340200. PMID 12042322.
"Entrez Gene: AUP1 ancient ubiquitous protein 1".

External links

Human AUP1 genome location and AUP1 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q9Y679 (Ancient ubiquitous protein 1) at the PDBe-KB.

Further reading

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Karpisheva KV, Tauber B, Kisliakova TV, Dobner T (2003). "[A new human cellular protein AUP1. III. The intracellular localization of AUP1 protein in different human and rat cell lines]". Tsitologiia. 44 (9): 846–51. PMID 12534238.
Karpisheva KV, Touber B, Kisliakova TV, Dobner T (2003). "[A new human cellular protein AUP1. II. cDNA cloning, genomic organization of Aup1 gene ans [sic] preliminary characterization of human AUP1 protein]". Tsitologiia. 44 (9): 839–45. PMID 12534237.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115307 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068328 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812468-5] Jang W, Weber JS, Bashir R, Bushby K, Meisler MH (Jan 1997). "Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13". Genomics. 36 (2): 366–8. doi:10.1006/geno.1996.0477. PMID 8812468.

[pmid12042322-6] Kato A, Kawamata N, Tamayose K, Egashira M, Miura R, Fujimura T, Murayama K, Oshimi K (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J Biol Chem. 277 (32): 28934–41. doi:10.1074/jbc.M204340200. PMID 12042322.

[entrez-7] "Entrez Gene: AUP1 ancient ubiquitous protein 1".

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