ASB6

ASB6
Identifiers
Aliases	ASB6, ankyrin repeat and SOCS box containing 6
External IDs	OMIM: 615051; MGI: 1919573; HomoloGene: 9895; GeneCards: ASB6; OMA:ASB6 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	129,642,169 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	30,720,345 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right frontal lobe; ; gastric mucosa; ; right hemisphere of cerebellum; ; prefrontal cortex; ; left adrenal cortex; ; middle temporal gyrus; ; right adrenal cortex; ; anterior cingulate cortex; ; skin of leg;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; granulocyte; ; yolk sac; ; lip; ; epiblast; ; right kidney; ; submandibular gland; ; neural layer of retina; ; embryo; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol;
Biological process	intracellular signal transduction; protein ubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	140459
	72323
	ENSG00000148331
	ENSMUSG00000039483
	Q9NWX5
	Q91ZU1
	NM_177999; NM_001202403; NM_017873
	NM_133346
	NP_001189332; NP_060343; NP_821066
	NP_579924
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin repeat and SOCS box protein 6 is a protein that in humans is encoded by the ASB6 gene.⁵

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.⁵

References

GRCh38: Ensembl release 89: ENSG00000148331 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000039483 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ASB6 ankyrin repeat and SOCS box-containing 6".

External links

Human ASB6 genome location and ASB6 gene details page in the UCSC Genome Browser.

Further reading

Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wilcox A, Katsanakis KD, Bheda F, Pillay TS (2004). "Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex". J. Biol. Chem. 279 (37): 38881–8. doi:10.1074/jbc.M406101200. PMID 15231829.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148331 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039483 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ASB6 ankyrin repeat and SOCS box-containing 6".

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