ASB13

ASB13
Identifiers
Aliases	ASB13, ankyrin repeat and SOCS box containing 13
External IDs	OMIM: 615055; MGI: 2145525; HomoloGene: 11666; GeneCards: ASB13; OMA:ASB13 - orthologs
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	3,703,822 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; right lobe of liver; ; kidney tubule; ; gastric mucosa; ; kidney; ; tibia; ; duodenum; ; metanephric glomerulus; ; Brodmann area 9; ; prefrontal cortex;
	Top expressed in
	deep cerebellar nuclei; ; medial vestibular nucleus; ; pontine nuclei; ; dorsal tegmental nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; inferior colliculi; ; globus pallidus; ; medial dorsal nucleus; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol;
Biological process	protein ubiquitination; intracellular signal transduction; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	79754
	142688
	n/a
	ENSMUSG00000033781
	Q8WXK3
	Q8VBX0
	NM_024701
	NM_001267724; NM_178283
	NP_078977
	NP_001254653; NP_840068
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin repeat and SOCS box protein 13 is a protein that in humans is encoded by the ASB13 gene.⁴⁵

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length sequences are not known.⁵

References

GRCm38: Ensembl release 89: ENSMUSG00000033781 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
"Entrez Gene: ASB13 ankyrin repeat and SOCS box-containing 13".

External links

Human ASB13 genome location and ASB13 gene details page in the UCSC Genome Browser.

Further reading

Kohroki J, Nishiyama T, Nakamura T, Masuho Y (2006). "ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes". FEBS Lett. 579 (30): 6796–802. doi:10.1016/j.febslet.2005.11.016. PMID 16325183. S2CID 7196353.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000033781 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12076535-4] Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.

[entrez-5] "Entrez Gene: ASB13 ankyrin repeat and SOCS box-containing 13".

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