ARHGAP19

ARHGAP19
Identifiers
Aliases	ARHGAP19, Rho GTPase activating protein 19
External IDs	OMIM: 611587; MGI: 1918335; HomoloGene: 13159; GeneCards: ARHGAP19; OMA:ARHGAP19 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,292,673 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,790,486 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; olfactory bulb; ; secondary oocyte; ; tibial nerve; ; spinal ganglia; ; glomerulus; ; metanephric glomerulus; ; testicle; ; gonad; ; ventricular zone;
	Top expressed in
	otolith organ; ; utricle; ; sciatic nerve; ; stroma of bone marrow; ; spermatocyte; ; primitive streak; ; lumbar spinal ganglion; ; hand; ; granulocyte; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity;
Cellular component	nucleus; cytosol; plasma membrane; intracellular membrane-bounded organelle; cytoplasm;
Biological process	positive regulation of GTPase activity; signal transduction; regulation of small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	84986
	71085
	ENSG00000213390
	ENSMUSG00000025154
	Q14CB8
	Q8BRH3
	NM_032900; NM_001204300; NM_001256423
	NM_001163495; NM_027667
	NP_001191229; NP_001243352; NP_116289
	NP_001156967; NP_081943
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GTPase-activating protein 19 is an enzyme that in humans is encoded by the ARHGAP19 gene.⁵

Mutations in the ARHGAP19 gene are linked to an inherited form of Charcot-Marie-Tooth disease⁶.

References

GRCh38: Ensembl release 89: ENSG00000213390 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025154 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ARHGAP19 Rho GTPase activating protein 19".
Dominik, Natalia; Efthymiou, Stephanie; Record, Christopher J.; Miao, Xinyu; Lin, Renee Q.; Parmar, Jevin M.; Scardamaglia, Annarita; Maroofian, Reza; Lowe, Simon A.; Aughey, Gabriel N.; Wilson, Abigail D.; Curro, Riccardo; Schnekenberg, Ricardo P.; Alavi, Shahryar; Leclaire, Leif (2025-12-01). "Biallelic variants in ARHGAP19 cause a progressive inherited motor-predominant neuropathy". Journal of Clinical Investigation. 135 (23). doi:10.1172/JCI184474. ISSN 1558-8238.

External links

Human ARHGAP19 genome location and ARHGAP19 gene details page in the UCSC Genome Browser.

Further reading

Lv L, Xu J, Zhao S, Chen C, Zhao X, Gu S, Ji C, Xie Y, Mao Y (June 2007). "Sequence analysis of a human RhoGAP domain-containing gene and characterization of its expression in human multiple tissues". DNA Sequence. 18 (3): 184–9. doi:10.1080/10425170600752965. PMID 17454002. S2CID 12855122.
Jikuya H, Takano J, Kikuno R, Hirosawa M, Nagase T, Nomura N, Ohara O (February 2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones". DNA Research. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.