ARFIP2

ARFIP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I49, 1I4D, 1I4L, 1I4T, 4DCN
Identifiers
Aliases	ARFIP2, POR1, ADP ribosylation factor interacting protein 2
External IDs	OMIM: 601638; MGI: 1924182; HomoloGene: 8234; GeneCards: ARFIP2; OMA:ARFIP2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,481,479 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	105,289,623 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; beta cell; ; body of pancreas; ; anterior pituitary; ; body of stomach; ; right uterine tube; ; trachea; ; rectum; ; minor salivary glands; ; right lobe of thyroid gland;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; lacrimal gland; ; superior frontal gyrus; ; pyloric antrum; ; genital tubercle; ; parotid gland; ; ventricular zone; ; tail of embryo; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-4-phosphate binding; protein domain specific binding; protein binding; GTP binding; identical protein binding; cadherin binding; GTP-dependent protein binding; phospholipid binding;
Cellular component	cell cortex; trans-Golgi network membrane; plasma membrane; ruffle; cytosol; cytoplasm;
Biological process	ruffle organization; small GTPase mediated signal transduction; actin cytoskeleton organization; regulation of Arp2/3 complex-mediated actin nucleation; lamellipodium assembly; intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
	23647
	76932
	ENSG00000132254
	ENSMUSG00000030881
	P53365
	Q8K221
	NM_001242854; NM_001242855; NM_001242856; NM_012402
	NM_029802
NP_001229783; NP_001229784; NP_001229785; NP_036534; NP_001357335;
	NP_001357337; NP_001357338; NP_001357340; NP_001357341; NP_001357342; NP_001363487; NP_001363488; NP_001363489; NP_001363490; NP_001363491; NP_001363492; NP_001363493
	NP_084078
	Wikidata
View/Edit Human	View/Edit Mouse

Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.⁵⁶⁷

Interactions

ARFIP2 has been shown to interact with Arf6,⁸⁹ ARF3,⁶ ARF5⁶⁹ and RAC1.⁵⁹¹⁰

References

GRCh38: Ensembl release 89: ENSG00000132254 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030881 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Van Aelst L, Joneson T, Bar-Sagi D (August 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15): 3778–86. doi:10.1002/j.1460-2075.1996.tb00751.x. PMC 452058. PMID 8670882.
Kanoh H, Williger BT, Exton JH (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
"Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".
D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801. S2CID 4324211.

External links

Human ARFIP2 genome location and ARFIP2 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132254 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030881 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8670882-5] Van Aelst L, Joneson T, Bar-Sagi D (August 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15): 3778–86. doi:10.1002/j.1460-2075.1996.tb00751.x. PMC 452058. PMID 8670882.

[pmid9038142-6] Kanoh H, Williger BT, Exton JH (February 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.

[entrez-7] "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".

[pmid9312003-8] D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.

[pmid11478794-9] Shin OH, Exton JH (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.

[pmid11346801-10] Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801. S2CID 4324211.

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Interactions

References

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External links