APOBEC3D

APOBEC3D
Identifiers
Aliases	APOBEC3D, A3D, APOBEC3DE, APOBEC3E, ARP6, apolipoprotein B mRNA editing enzyme catalytic subunit 3D, A3DE
External IDs	OMIM: 609900; HomoloGene: 122788; GeneCards: APOBEC3D; OMA:APOBEC3D - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,033,277 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; spleen; ; bone marrow cell; ; blood; ; appendix; ; right uterine tube; ; monocyte; ; gallbladder; ; rectum;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; zinc ion binding; catalytic activity; hydrolase activity; metal ion binding; RNA binding; cytidine deaminase activity;
Cellular component	cytoplasm; P-body; nucleus;
Biological process	negative regulation of transposition; innate immune response; defense response to virus; DNA cytosine deamination; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; immune system process; cytidine deamination; cytidine to uridine editing; DNA demethylation;
	Sources:Amigo / QuickGO
Orthologs
	140564
	n/a
	ENSG00000243811
	n/a
	B2CML4
	n/a
	NM_152426; NM_001363781
	n/a
	NP_689639; NP_001350710
	n/a
	Wikidata
View/Edit Human

Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene.³⁴

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.⁴

References

GRCh38: Ensembl release 89: ENSG00000243811 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics. 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.
"Entrez Gene: APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative)".

Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family. Dang Y, Wang X, Esselman WJ, Zheng YH. J Virol. 2006 Nov;80(21):10522-33. doi: 10.1128/JVI.01123-06. Epub 2006 Aug 18.

External links

Human APOBEC3D genome location and APOBEC3D gene details page in the UCSC Genome Browser.

Further reading

Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business". Trends Genet. 19 (4): 207–16. doi:10.1016/S0168-9525(03)00054-4. PMID 12683974.
Harris RS, Liddament MT (2004). "Retroviral restriction by APOBEC proteins". Nat. Rev. Immunol. 4 (11): 868–77. doi:10.1038/nri1489. PMID 15516966. S2CID 10789405.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mariani R, Chen D, Schröfelbauer B, et al. (2003). "Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif". Cell. 114 (1): 21–31. doi:10.1016/S0092-8674(03)00515-4. PMID 12859895.
Sawyer SL, Emerman M, Malik HS (2006). "Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G". PLOS Biol. 2 (9): E275. doi:10.1371/journal.pbio.0020275. PMC 479043. PMID 15269786.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10) R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Dang Y, Wang X, Esselman WJ, Zheng YH (2006). "Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family". J. Virol. 80 (21): 10522–33. doi:10.1128/JVI.01123-06. PMC 1641744. PMID 16920826.
Kinomoto M, Kanno T, Shimura M, et al. (2007). "All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition". Nucleic Acids Res. 35 (9): 2955–64. doi:10.1093/nar/gkm181. PMC 1888823. PMID 17439959.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000243811 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11863358-3] Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics. 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.

[entrez-4] "Entrez Gene: APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative)".

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