Adaptor-related protein complex 2, alpha 1

AP2A1
Identifiers
Aliases	AP2A1, ADTAA, AP2-ALPHA, CLAPA1, Adaptor-related protein complex 2, alpha 1, adaptor related protein complex 2 alpha 1 subunit, adaptor related protein complex 2 subunit alpha 1
External IDs	OMIM: 601026; MGI: 101921; HomoloGene: 68997; GeneCards: AP2A1; OMA:AP2A1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)1 Band 19q13.33 Start 49,767,001 bp1 End 49,807,114 bp1
Gene location (Mouse) Chr. Chromosome 7 (mouse)2 Band 7|7 B3 Start 44,549,797 bp2 End 44,578,920 bp2
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex left testis right testis right hemisphere of cerebellum right frontal lobe Brodmann area 9 right ovary Top expressed in superior frontal gyrus spermatid primary visual cortex dentate gyrus of hippocampal formation granule cell spermatocyte muscle of thigh neural layer of retina lip cerebellar cortex ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function protein C-terminus binding clathrin adaptor activity protein-containing complex binding protein binding protein kinase binding low-density lipoprotein particle receptor binding Cellular component endocytic vesicle membrane cytosol filopodium tip membrane coat apical plasma membrane endolysosome membrane clathrin adaptor complex basolateral plasma membrane clathrin-coated pit clathrin coat of trans-Golgi network vesicle clathrin-coated endocytic vesicle membrane AP-2 adaptor complex membrane plasma membrane clathrin-coated vesicle protein-containing complex clathrin-coated endocytic vesicle Biological process ephrin receptor signaling pathway mitigation of host defenses by virus clathrin-dependent endocytosis antigen processing and presentation of exogenous peptide antigen via MHC class II Golgi to endosome transport transport protein transport vesicle-mediated transport intracellular protein transport endocytosis microtubule-based movement Wnt signaling pathway, planar cell polarity pathway negative regulation of hyaluronan biosynthetic process membrane organization low-density lipoprotein particle receptor catabolic process low-density lipoprotein particle clearance positive regulation of neuron projection development positive regulation of receptor-mediated endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 160 11771 Ensembl ENSG00000196961 ENSMUSG00000060279 UniProt O95782 P17426 RefSeq (mRNA) NM_014203 NM_130787 NM_001077264 NM_007458 RefSeq (protein) NP_055018 NP_570603 NP_001070732 NP_031484 Location (UCSC) Chr 19: 49.77 – 49.81 Mb Chr 7: 44.55 – 44.58 Mb PubMed search 3 4
Wikidata
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AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.⁵

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.⁶

Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2⁷ and NUMB.⁷