AOC2

AOC2
Identifiers
Aliases	AOC2, DAO2, RAO, amine oxidase, copper containing 2, SSAO, amine oxidase copper containing 2
External IDs	OMIM: 602268; MGI: 2668431; HomoloGene: 56457; GeneCards: AOC2; OMA:AOC2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)1 Band 17q21.31 Start 42,844,580 bp1 End 42,850,707 bp1
Gene location (Mouse) Chr. Chromosome 11 (mouse)2 Band 11|11 D Start 101,215,889 bp2 End 101,220,528 bp2
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm testicle periodontal fiber secondary oocyte gonad blood cartilage tissue tibia right lobe of liver subcutaneous adipose tissue Top expressed in bone marrow white adipose tissue adrenal gland islet of Langerhans granulocyte ganglionic eminence ventricular zone jejunum neural layer of retina duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function electron transfer activity tryptamine:oxygen oxidoreductase (deaminating) activity aliphatic-amine oxidase activity oxidoreductase activity phenethylamine:oxygen oxidoreductase (deaminating) activity copper ion binding metal ion binding quinone binding aminoacetone:oxygen oxidoreductase(deaminating) activity primary amine oxidase activity Cellular component cytoplasm plasma membrane membrane Biological process xenobiotic metabolic process amine metabolic process catecholamine metabolic process visual perception electron transport chain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 314 237940 Ensembl ENSG00000131480 ENSMUSG00000078651 UniProt O75106 Q812C9 RefSeq (mRNA) NM_009590 NM_001158 NM_178932 RefSeq (protein) NP_001149 NP_033720 NP_849263 Location (UCSC) Chr 17: 42.84 – 42.85 Mb Chr 11: 101.22 – 101.22 Mb PubMed search 3 4
Wikidata
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Amine oxidase, copper containing 2 (AOC2) is a protein that in humans is encoded by the AOC2 gene.⁵ The protein is a copper-containing primary amine oxidase enzyme.

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.