AMP deaminase 2

AMPD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NO3, 4NO5
Identifiers
Aliases	AMPD2, PCH9, SPG63, adenosine monophosphate deaminase 2
External IDs	OMIM: 102771; MGI: 88016; HomoloGene: 2979; GeneCards: AMPD2; OMA:AMPD2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	109,632,051 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	107,993,967 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; granulocyte; ; nucleus accumbens; ; pancreatic ductal cell; ; stromal cell of endometrium; ; right frontal lobe; ; monocyte; ; putamen; ; caudate nucleus; ; blood;
	Top expressed in
	fossa; ; arcuate nucleus; ; ventromedial nucleus; ; condyle; ; mammillary body; ; motor neuron; ; internal carotid artery; ; Rostral migratory stream; ; external carotid artery; ; lateral hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; metal ion binding; deaminase activity; protein binding; AMP deaminase activity;
Cellular component	cellular component; cytosol;
Biological process	purine ribonucleoside monophosphate biosynthetic process; IMP salvage; cyclic purine nucleotide metabolic process; nucleotide metabolic process; purine-containing compound salvage; IMP biosynthetic process; energy homeostasis; AMP metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	271
	109674
	ENSG00000116337
	ENSMUSG00000027889
	Q01433
	Q9DBT5
NM_001257360; NM_001257361; NM_001308170; NM_004037; NM_139156;
	NM_203404; NM_001368809
	NM_001289719; NM_001289720; NM_028779; NM_001346665
NP_001244289; NP_001244290; NP_001295099; NP_004028; NP_631895;
	NP_001355738
	NP_001276648; NP_001276649; NP_001333594; NP_083055
	Wikidata
View/Edit Human	View/Edit Mouse

AMP deaminase 2 is an enzyme that in humans is encoded by the AMPD2 gene.⁵⁶

High AMPD2 expression levels correlate with poor patient outcome and a proliferative tumor phenotype in undifferentiated pleomorphic sarcoma (UPS). ⁷

References

GRCh38: Ensembl release 89: ENSG00000116337 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027889 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mahnke-Zizelman DK, Sabina RL (Nov 1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons". J Biol Chem. 267 (29): 20866–77. doi:10.1016/S0021-9258(19)36768-7. PMID 1400401.
"Entrez Gene: AMPD2 adenosine monophosphate deaminase 2 (isoform L)".
Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, et al. (September 2018). "Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma". International Journal of Cancer. 144 (4): 859–867. doi:10.1002/ijc.31903. PMID 30267407.

External links

Human AMPD2 genome location and AMPD2 gene details page in the UCSC Genome Browser.

Further reading

Bausch-Jurken MT, Mahnke-Zizelman DK, Morisaki T, Sabina RL (1992). "Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA". J. Biol. Chem. 267 (31): 22407–13. doi:10.1016/S0021-9258(18)41686-9. PMID 1429593.
Van den Bergh F, Sabina RL (1996). "Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L". Biochem. J. 312 (Pt 2): 401–10. doi:10.1042/bj3120401. PMC 1136276. PMID 8526848.
Mahnke-Zizelman DK, van den Bergh F, Bausch-Jurken MT, et al. (1996). "Cloning, sequence and characterization of the human AMPD2 gene: evidence for transcriptional regulation by two closely spaced promoters". Biochim. Biophys. Acta. 1308 (2): 122–32. doi:10.1016/0167-4781(96)00089-9. PMID 8764830.
Haas AL, Sabina RL (2003). "N-terminal extensions of the human AMPD2 polypeptide influence ATP regulation of isoform L". Biochem. Biophys. Res. Commun. 305 (2): 421–7. doi:10.1016/S0006-291X(03)00787-3. PMID 12745092.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116337 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027889 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1400401-5] Mahnke-Zizelman DK, Sabina RL (Nov 1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons". J Biol Chem. 267 (29): 20866–77. doi:10.1016/S0021-9258(19)36768-7. PMID 1400401.

[entrez-6] "Entrez Gene: AMPD2 adenosine monophosphate deaminase 2 (isoform L)".

[7] Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, et al. (September 2018). "Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma". International Journal of Cancer. 144 (4): 859–867. doi:10.1002/ijc.31903. PMID 30267407.

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